Abstract：
Due to lack of amino sugar with aging, people will suffer from various epidemic bone diseases called \"undead cancer\" by the World Health Organization. The key problem in bone tissue engineering that is not completely resolved is the repair of critical large-scale bone and cartilage defects. The chirality of the extracellular matrix plays a decisive role in the physiological activity of bone cells and the occurrence of bone tissue, but the mechanism of chirality in regulating cell adhesion and growth is still in the early stage of exploration. The application progress of chirality-induced bionic scaffolds is reviewed here in bone defects repair based on \"soft\" and \"hard\" scaffolds. The aim is to summarize the effects of different chiral structures (l-shaped and d-shaped) in the process of inducing bionic scaffolds in bone defects repair. In addition, many technologies and methods as well as issues worthy of special consideration for preparing chirality-induced bionic scaffolds are also introduced. It is expected that this work can provide inspiring ideas for designing new chirality-induced bionic scaffolds and promote the development of chirality in bone tissue engineering.
摘要：
由于缺乏氨基糖与老化，人们将患有各种被世界卫生组织称为“不死癌症”的流行性骨病。骨组织工程中尚未完全解决的关键问题是修复严重的大规模骨和软骨缺损。细胞外基质的手性对骨细胞的生理活动和骨组织的发生起着决定性的作用,但手性调节细胞粘附和生长的机制仍处于早期探索阶段。本文综述了基于“软”和“硬”支架的手性仿生支架在骨缺损修复中的应用进展。目的总结不同手性结构(l形和d形)在诱导仿生支架修复骨缺损过程中的作用。此外,还介绍了制备手性诱导仿生支架的许多技术和方法以及值得特别考虑的问题。期望这项工作可以为设计新型手性诱导仿生支架提供鼓舞人心的思路，并促进手性在骨组织工程中的发展。
