Abstract：
Active SARS-CoV-2 infection is confirmed mainly through the detection of viral nucleic acid via the reverse transcriptase polymerase chain reaction (RT-PCR) technique. Methods to assess humoral responses contribute to the monitoring of the disease and confirmation of exposure to the virus.
To evaluate the accuracy of tests for IgM and IgG antibodies for SARS-CoV-2 infection confirmed by RT-PCR and utility as complementary data for immunosurveillance.
Literature research was performed by searching the terms \"COVID-19\", \"COVID-19 diagnostic testing\" and \"test\" in the databases MEDLINE, EMBASE, Cochrane Library, Web of Science and Cumulative Index to Nursing and Allied Health Literature to search for potentially eligible observational studies without language restrictions published up to September 2020.
The pooled sensitivity and specificity, regardless of collection moment, was 80.0% (CI 95% 72.0-86.0) and 97.0% (CI 95% 94.0-98.0) for \"IgM and/or IgG\", respectively. Serology considering immunoglobulins M and G together had a high accuracy performance on \"fifteenth day and after\": sensitivity and specificity was 91.0% (CI 95% 85.0-94.0) and 98.0% (CI 95% 95.0-99.0) respectively, DOR 461 and AUC 0.98.
This study shows that serology is a group of tests with high accuracy, mainly following the second week after infection.
To evaluate the accuracy of tests for IgM and IgG antibodies for SARS-CoV-2 infection confirmed by RT-PCR and utility as complementary data for immunosurveillance.
Literature research was performed by searching the terms \"COVID-19\", \"COVID-19 diagnostic testing\" and \"test\" in the databases MEDLINE, EMBASE, Cochrane Library, Web of Science and Cumulative Index to Nursing and Allied Health Literature to search for potentially eligible observational studies without language restrictions published up to September 2020.
The pooled sensitivity and specificity, regardless of collection moment, was 80.0% (CI 95% 72.0-86.0) and 97.0% (CI 95% 94.0-98.0) for \"IgM and/or IgG\", respectively. Serology considering immunoglobulins M and G together had a high accuracy performance on \"fifteenth day and after\": sensitivity and specificity was 91.0% (CI 95% 85.0-94.0) and 98.0% (CI 95% 95.0-99.0) respectively, DOR 461 and AUC 0.98.
This study shows that serology is a group of tests with high accuracy, mainly following the second week after infection.
摘要：
主要通过逆转录酶聚合酶链反应（RT-PCR）技术检测病毒核酸来确认活动性SARS-CoV-2感染。评估体液反应的方法有助于监测疾病和确认暴露于病毒。
评估通过RT-PCR确认的SARS-CoV-2感染的IgM和IgG抗体测试的准确性，并将其用作免疫监视的补充数据。
通过搜索术语“COVID-19”进行文献研究，MEDLINE数据库中的“COVID-19诊断测试”和“测试”，EMBASE,科克伦图书馆,WebofScience和护理和相关健康文献累积索引，以搜索截至2020年9月发布的无语言限制的潜在合格观察性研究。
合并的敏感性和特异性，不管收集时间，“IgM和/或IgG”为80.0%（CI95%72.0-86.0）和97.0%（CI95%94.0-98.0），分别。考虑免疫球蛋白M和G的血清学在“第15天和之后”具有很高的准确性：灵敏度和特异性分别为91.0％（CI95％85.0-94.0）和98.0％（CI95％95.0-99.0），DOR461和AUC0.98。
这项研究表明，血清学是一组准确性很高的测试，主要是在感染后第二周。
评估通过RT-PCR确认的SARS-CoV-2感染的IgM和IgG抗体测试的准确性，并将其用作免疫监视的补充数据。
通过搜索术语“COVID-19”进行文献研究，MEDLINE数据库中的“COVID-19诊断测试”和“测试”，EMBASE,科克伦图书馆,WebofScience和护理和相关健康文献累积索引，以搜索截至2020年9月发布的无语言限制的潜在合格观察性研究。
合并的敏感性和特异性，不管收集时间，“IgM和/或IgG”为80.0%（CI95%72.0-86.0）和97.0%（CI95%94.0-98.0），分别。考虑免疫球蛋白M和G的血清学在“第15天和之后”具有很高的准确性：灵敏度和特异性分别为91.0％（CI95％85.0-94.0）和98.0％（CI95％95.0-99.0），DOR461和AUC0.98。
这项研究表明，血清学是一组准确性很高的测试，主要是在感染后第二周。
