Abstract：
An updated analysis of neglected tropical diseases (NTDs) from a global perspective is missing from the literature. We aimed to assess the global burden and trends of NTDs from 1990 to 2019.
Yearly incident case, mortality and disability-adjusted life years (DALYs) data for NTDs were extracted from the Global Burden of Disease Study 2019 (GBD 2019) based on global, regional, country, social development index (SDI), age and sex categories. The age-standardized rate (ASR) and number of incident cases, mortality and DALYs were computed from 1990 to 2019. The estimated annual percentage change (EAPC) in the ASR was calculated to quantify the changing trend.
Globally, the age-standardized incidence rate (ASIR) and the number of incident cases of total NTDs increased between 1990 and 2019, whereas the age-standardized mortality rate (ASMR), mortality, age-standardized DALY rate and DALYs of total NTDs decreased. Although tropical Latin America, South Asia, Southeast Asia and Oceania had the highest ASIR for total NTDs in 2019, tropical Latin America was the only region to experience a decreasing trend in ASIR from 1673.5 per 100 000 in 2010 to 1059.2 per 100 000 in 2019. The middle, high-middle and high SDI regions experienced increasing ASIR trends between 1990 and 2019, whereas the low-middle SDI region remained stable, and the low SDI region presented a decreasing trend. Children and older adults were vulnerable to dengue, rabies and leishmaniasis (cutaneous and mucocutaneous). Females had a higher ASIR but a lower ASMR and age-standardized DALY rate than males.
NTDs still represent a serious problem for public health, and the increasing ASIR and incident cases globally may require more targeted strategies for prevention, control and surveillance, especially among specific populations and endemic areas.
Yearly incident case, mortality and disability-adjusted life years (DALYs) data for NTDs were extracted from the Global Burden of Disease Study 2019 (GBD 2019) based on global, regional, country, social development index (SDI), age and sex categories. The age-standardized rate (ASR) and number of incident cases, mortality and DALYs were computed from 1990 to 2019. The estimated annual percentage change (EAPC) in the ASR was calculated to quantify the changing trend.
Globally, the age-standardized incidence rate (ASIR) and the number of incident cases of total NTDs increased between 1990 and 2019, whereas the age-standardized mortality rate (ASMR), mortality, age-standardized DALY rate and DALYs of total NTDs decreased. Although tropical Latin America, South Asia, Southeast Asia and Oceania had the highest ASIR for total NTDs in 2019, tropical Latin America was the only region to experience a decreasing trend in ASIR from 1673.5 per 100 000 in 2010 to 1059.2 per 100 000 in 2019. The middle, high-middle and high SDI regions experienced increasing ASIR trends between 1990 and 2019, whereas the low-middle SDI region remained stable, and the low SDI region presented a decreasing trend. Children and older adults were vulnerable to dengue, rabies and leishmaniasis (cutaneous and mucocutaneous). Females had a higher ASIR but a lower ASMR and age-standardized DALY rate than males.
NTDs still represent a serious problem for public health, and the increasing ASIR and incident cases globally may require more targeted strategies for prevention, control and surveillance, especially among specific populations and endemic areas.
摘要：
文献中缺少从全球角度对被忽视的热带病（NTD）的最新分析。我们旨在评估1990年至2019年NTD的全球负担和趋势。
年度突发事件,NTDs的死亡率和残疾调整生命年(DALYs)数据来自2019年全球疾病负担研究(GBD2019)，基于全球，区域,国家,社会发展指数(SDI)年龄和性别类别。年龄标准化率(ASR)和事件病例数，死亡率和DALY是1990年至2019年计算的。计算ASR中估计的年度百分比变化(EAPC)以量化变化趋势。
全球,1990年至2019年间，年龄标准化发病率(ASIR)和总NTD的事件病例数增加，而年龄标准化死亡率(ASMR)，死亡率,总NTDs的年龄标准化DALY率和DALYs下降。虽然热带拉丁美洲，南亚,东南亚和大洋洲在2019年的总NTDASIR最高，热带拉丁美洲是唯一经历ASIR下降趋势的地区，从2010年的1673.5/100000下降到2019年的1059.2/100000。中间的,中高SDI和高SDI地区在1990年至2019年期间经历了增加的ASIR趋势，而中低SDI地区保持稳定，低SDI区域呈现下降趋势。儿童和老年人容易感染登革热，狂犬病和利什曼病（皮肤和皮肤粘膜）。女性的ASIR较高，但ASMR和年龄标准化的DALY率低于男性。
NTD仍然是一个严重的公共卫生问题，全球越来越多的ASIR和事件病例可能需要更有针对性的预防策略，控制和监视,特别是在特定人群和流行地区。
年度突发事件,NTDs的死亡率和残疾调整生命年(DALYs)数据来自2019年全球疾病负担研究(GBD2019)，基于全球，区域,国家,社会发展指数(SDI)年龄和性别类别。年龄标准化率(ASR)和事件病例数，死亡率和DALY是1990年至2019年计算的。计算ASR中估计的年度百分比变化(EAPC)以量化变化趋势。
全球,1990年至2019年间，年龄标准化发病率(ASIR)和总NTD的事件病例数增加，而年龄标准化死亡率(ASMR)，死亡率,总NTDs的年龄标准化DALY率和DALYs下降。虽然热带拉丁美洲，南亚,东南亚和大洋洲在2019年的总NTDASIR最高，热带拉丁美洲是唯一经历ASIR下降趋势的地区，从2010年的1673.5/100000下降到2019年的1059.2/100000。中间的,中高SDI和高SDI地区在1990年至2019年期间经历了增加的ASIR趋势，而中低SDI地区保持稳定，低SDI区域呈现下降趋势。儿童和老年人容易感染登革热，狂犬病和利什曼病（皮肤和皮肤粘膜）。女性的ASIR较高，但ASMR和年龄标准化的DALY率低于男性。
NTD仍然是一个严重的公共卫生问题，全球越来越多的ASIR和事件病例可能需要更有针对性的预防策略，控制和监视,特别是在特定人群和流行地区。
