Abstract：
Geraniol, a component of essential oil, is reported to have various pharmacological properties. The current study was conducted to demonstrate the dose-dependent neurobehavioral effects of geraniol. Rats were divided into 5 groups (n=7), comprising of control and four test groups for different doses of geraniol including 10, 30, 50 and 100 mg/kg. Geraniol was given for 15 days through intraperitoneal route. Following the administration, anxiety-, depression-like behaviors and memory function were evaluated. Extent of oxidative stress in rat\'s brain was also assessed by determining the levels of malondialdehyde and antioxidant enzymes activity. The present study revealed that low doses of geraniol produced more potent anxiolytic, antidepressant, nootropic, and antioxidant effects as compared to the higher doses. The findings highlight the dual characteristic of geraniol, acting as antioxidant at lower doses while at higher doses it produces pro-oxidant effects. The results are discussed in the context of dual characteristic of antioxidant compounds.
摘要：
香叶醇,精油的成分，据报道具有各种药理特性。进行本研究以证明香叶醇的剂量依赖性神经行为效应。将大鼠分为5组(n=7),包括对照组和四个不同剂量的香叶醇的测试组，包括10、30、50和100mg/kg。通过腹膜内途径给予香叶醇15天。在政府之后,焦虑--,评估抑郁样行为和记忆功能。还通过测定丙二醛水平和抗氧化酶活性来评估大鼠大脑中的氧化应激程度。本研究表明，低剂量的香叶醇产生更有效的抗焦虑，抗抑郁药,促智,和抗氧化作用相比，较高的剂量。研究结果突出了香叶醇的双重特性，在较低剂量时作为抗氧化剂，而在较高剂量时产生促氧化剂作用。在抗氧化剂化合物的双重特征的背景下讨论了结果。
