Mesh : Adult Eczema HTLV-I Infections / complications Human T-lymphotropic virus 1 Humans Leukemia-Lymphoma, Adult T-Cell / complications Lymphoma Male Skin Diseases, Infectious / complications Young Adult

来  源:   DOI:10.1097/DAD.0000000000002044

Abstract:
UNASSIGNED: The human T-cell lymphotropic virus type 1 is a retrovirus that may cause severe diseases such as infective dermatitis associated with HTLV-1 (IDH) and adult T-cell leukemia/lymphoma (ATL). IDH is a chronic relapsing infected eczema of childhood, and ATL is a distinct type of peripheral T-cell leukemia/lymphoma, which is classified into the following types: smoldering, primary cutaneous tumoral, chronic, lymphoma, and acute. Progression of IDH to ATL during the course of IDH has been previously reported in 3 young patients, two of them from Bahia (Brazil). We present the case of a 22-year-old man who had IDH since childhood and developed ATL 18 months ago. The lymphoma lesions were superimposed on previously existing IDH lesions (forehead, axillae, umbilical area, and neck) or in areas generally affected by IDH (external genitalia, hypogastrium, groin, and eyelid). Cutaneous lesions in ATL are very frequent, but in this patient, besides infiltrated plaques and papules presented vesicles on the skin corresponding histologically to dilated Pautrier abscesses. Vesicular ATL is a rare condition. This case constitutes a very demonstrative example of the close correlation between IDH and ATL.
摘要:
未经证实:人类1型T细胞淋巴病毒是一种逆转录病毒,可能导致严重的疾病,例如与HTLV-1(IDH)和成人T细胞白血病/淋巴瘤(ATL)相关的感染性皮炎。IDH是一种儿童慢性复发性感染湿疹,ATL是一种独特的外周T细胞白血病/淋巴瘤,它分为以下类型:阴燃,原发性皮肤肿瘤,慢性,淋巴瘤和急性。在IDH的过程中,IDH向ATL的进展先前已在3名年轻患者中报道,其中两人来自巴伊亚州(巴西)。我们介绍了一名22岁男子的病例,他从小就患有IDH,并在18个月前发展为ATL。淋巴瘤病变叠加在先前存在的IDH病变上(前额,腋窝,脐带区,和颈部)或通常受IDH(外生殖器,胃下,腹股沟,和眼睑)。ATL的皮肤病变非常常见,但是在这个病人身上,除了浸润的斑块和丘疹在组织学上与扩张的Pautrier脓肿相对应的皮肤上出现囊泡。囊泡ATL是一种罕见的疾病。这种情况构成了IDH和ATL之间密切相关的一个非常明显的例子。
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