PDF(Pubmed)
Abstract：
Steroid hormones are responsible for coordinating many aspects of biological processes in most multicellular organisms, including insects. Ecdysteroid, the principal insect steroid hormone, is biosynthesized from dietary cholesterol or plant sterols. In the last 20 years, a number of ecdysteroidogenic enzymes, including Noppera-bo, Neverland, Shroud, Spook/Spookier, Cyp6t3, Phantom, Disembodied, Shadow, and Shade, have been identified and characterized in molecular genetic studies using the fruit fly Drosophila melanogaster. These enzymes are encoded by genes collectively called the Halloween genes. The transcriptional regulatory network, governed by multiple regulators of transcription, chromatin remodeling, and endoreplication, has been shown to be essential for the spatiotemporal expression control of Halloween genes in D. melanogaster. In this review, we summarize the latest information on transcriptional regulators that are crucial for controlling the expression of ecdysteroid biosynthetic enzymes and their roles in insect development.
摘要：
类固醇激素负责协调大多数多细胞生物体中生物过程的许多方面，包括昆虫。Ecdysteroid,主要的昆虫类固醇激素，是从膳食胆固醇或植物甾醇生物合成的。在过去的20年里,一些蜕皮酶，包括诺佩拉-博,梦幻岛,裹尸布,幽灵/幽灵，Cyp6t3幻影,无形的，影子,还有Shade,已使用果蝇果蝇果蝇在分子遗传学研究中进行了鉴定和表征。这些酶由统称为万圣节基因的基因编码。转录调控网络，由多个转录调节因子控制，染色质重塑，和内复制，已被证明对于黑腹D.的万圣节基因的时空表达控制至关重要。在这次审查中,我们总结了有关转录调节因子的最新信息，这些转录调节因子对于控制蜕皮类固醇生物合成酶的表达及其在昆虫发育中的作用至关重要。
