Abstract：
In this study, the clinicopathologic features and survival outcomes of patients with hyperpigmented MF from a single tertiary referral center database were retrospectively evaluated. Hyperpigmented MF accounted for 10.9% (14/128) of all MF cases. The mean age at diagnosis was 46.9 years, and the female-to-male ratio was 1:1.3. Concurrent hypopigmented, ichthyosiform, and poikilodermatous lesions were detected in 21.4%, 14.3%, and 14.3% of the patients, respectively. Histopathologically, most patients (85.7%) showed interface change with pigment incontinence. Double negative (CD4- and CD8-) immunophenotypes were more frequent in patients with hyperpigmented MF (25%) than in those with other MF subtypes (9.8%). Most patients (85.7%) had early-stage disease at diagnosis. The survival outcomes did not differ significantly between hyperpigmented and other MF subtypes. In conclusion, hyperpigmented MF often accompanies other atypical MF variants and is frequently associated with atypical immunophenotypes. The outcomes of hyperpigmented MF are comparable to those of other MF subtypes.
摘要：
在这项研究中,我们对来自一个三级转诊中心数据库的色素沉着型MF患者的临床病理特征和生存结局进行了回顾性评估.色素沉着型MF占所有MF病例的10.9%(14/128)。诊断时的平均年龄是46.9岁,男女比例为1:1.3。并发色素减退，鱼鳞状,并且在21.4％的患者中发现了多皮病，14.3%,和14.3%的病人,分别。组织病理学,大多数患者（85.7％）表现为色素失禁的界面改变。高色素MF患者（25％）的双阴性（CD4-和CD8-）免疫表型比其他MF亚型（9.8％）的患者更常见。大多数患者（85.7％）在诊断时患有早期疾病。高色素沉着型和其他MF亚型之间的生存结果没有显着差异。总之,色素沉着的MF常伴随着其他非典型的MF变异体,并常与非典型的免疫表型相关.色素沉着MF的结果与其他MF亚型的结果相当。
