关键词: Alzheimer Parkinson magnetoelectric nanoparticles psychiatry

Mesh : Brain Humans Mental Disorders / diagnosis therapy Nanomedicine Nanoparticles / therapeutic use Neurodegenerative Diseases / drug therapy

来  源:   DOI:10.1002/wnan.1781

Abstract:
Almost 1000 million people have recently been diagnosed with a mental health or substance disorder (Ritchie & Roser, 2018). Psychiatric disorders, and their treatment, represent a big burden to the society worldwide, causing about 8 million deaths per year (Walker et al., 2015). Daily progress in science enables continuous advances in methods to treat patients; however, the brain remains to be the most unknown and complex organ of the body. There is a growing demand for innovative approaches to treat psychiatric as well as neurodegenerative disorders, disorders with unknown curability, and treatments mostly designed to slow disease progression. Based on that need and the peculiarity of the central nervous system, in the present review, we highlight the handicaps of the existing approaches as well as discuss the potential of the recently introduced magnetoelectric nanoparticles (MENPs) to become a game-changing tool in future applications for the treatment of brain alterations. Unlike other stimulation approaches, MENPs have the potential to enable a wirelessly controlled stimulation at a single-neuron level without requiring genetic modification of the neural tissue and no toxicity has yet been reported. Their potential as a new tool for targeting the brain is discussed. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Disease Therapeutic Approaches and Drug Discovery > Neurological Disease.
摘要:
最近有近1000万人被诊断出患有精神健康或物质紊乱(Ritchie&Roser,2018)。精神病,和他们的治疗,对全世界的社会来说是一个巨大的负担,每年造成约800万人死亡(Walker等人。,2015).科学的日常进步使治疗患者的方法不断进步;然而,大脑仍然是人体最未知和最复杂的器官。对治疗精神病和神经退行性疾病的创新方法的需求不断增长,具有未知可治愈性的疾病,和主要旨在减缓疾病进展的治疗方法。基于这种需要和中枢神经系统的特点,在本次审查中,我们强调了现有方法的缺陷,并讨论了最近引入的磁电纳米粒子(MENP)在未来治疗大脑改变的应用中成为改变游戏规则的工具的潜力。与其他刺激方法不同,MENP具有在单神经元水平上实现无线控制刺激的潜力,而不需要对神经组织进行遗传修饰,并且尚未报道毒性。讨论了它们作为靶向大脑的新工具的潜力。本文分为:治疗方法和药物发现>心血管疾病的纳米药物治疗方法和药物发现>神经系统疾病。
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