Abstract：
Very few recent nationwide studies have assessed the epidemiology of cleft lip with or without palate (CL/P). The purpose of this study was to identify the prevalence, risk of premature births, mortality and cause of death of CL/P.
This nationwide population-based cohort study evaluated all 5 747 830 live births in South Korea, including CL/P infants, from 2006 to 2018. The prevalence with trend analysis, risk of premature births, mortality and cause of death of CL/P with or without associated syndromes (non-syndromic, syndromic CL/P) and subgroups (cleft lip only, cleft palate only, cleft lip with palate) were evaluated.
Among 5 747 830 live births, 11 284 children were identified as having CL/P during the study period. The annual prevalence was 1.96 per 1000 births. The prevalence ratio, which shows the trend during the period, was 1.021. Both non-syndromic and syndromic CL/P children had higher risk of premature births compared with children without CL/P (odds ratio: non-syndromic 1.43, syndromic 5.29). The mortality rates per 1000 person-years were 0.39 for children without CL/P, 0.98 for non-syndromic CL/P children and 12.20 for syndromic CL/P children. The causes of deaths were not different for children without CL/P in non-syndromic CL/P, but the most common cause of deaths was cardiovascular anomalies in syndromic CL/P.
The reported prevalence of 1.96 per 1000 births is one of the highest prevalences worldwide. CL/P children had high risks of premature births and risk of mortality. The most common cause of deaths was cardiovascular anomalies.
This nationwide population-based cohort study evaluated all 5 747 830 live births in South Korea, including CL/P infants, from 2006 to 2018. The prevalence with trend analysis, risk of premature births, mortality and cause of death of CL/P with or without associated syndromes (non-syndromic, syndromic CL/P) and subgroups (cleft lip only, cleft palate only, cleft lip with palate) were evaluated.
Among 5 747 830 live births, 11 284 children were identified as having CL/P during the study period. The annual prevalence was 1.96 per 1000 births. The prevalence ratio, which shows the trend during the period, was 1.021. Both non-syndromic and syndromic CL/P children had higher risk of premature births compared with children without CL/P (odds ratio: non-syndromic 1.43, syndromic 5.29). The mortality rates per 1000 person-years were 0.39 for children without CL/P, 0.98 for non-syndromic CL/P children and 12.20 for syndromic CL/P children. The causes of deaths were not different for children without CL/P in non-syndromic CL/P, but the most common cause of deaths was cardiovascular anomalies in syndromic CL/P.
The reported prevalence of 1.96 per 1000 births is one of the highest prevalences worldwide. CL/P children had high risks of premature births and risk of mortality. The most common cause of deaths was cardiovascular anomalies.
摘要：
最近很少有全国性研究评估有或没有腭裂（CL/P）的唇裂的流行病学。这项研究的目的是确定患病率，早产的风险，CL/P的死亡率和死亡原因
这项基于全国人群的队列研究评估了韩国所有5747830例活产，包括CL/P婴儿，从2006年到2018年。流行趋势分析，早产的风险，有或没有相关综合征的CL/P的死亡率和死亡原因(非综合征，综合征CL/P）和亚组（仅唇裂，只有腭裂,唇腭裂）进行评估。
在5747830例活产中，在研究期间，有11284名儿童被确定为患有CL/P。年患病率为每1000名新生儿1.96名。患病率，这显示了这一时期的趋势，是1.021。与非综合征性和综合征性CL/P儿童相比，非综合征性和综合征性CL/P儿童的早产风险更高（比值比：非综合征性1.43，综合征性5.29）。无CL/P儿童的每1000人年死亡率为0.39，非综合征性CL/P儿童为0.98，综合征性CL/P儿童为12.20。非综合征性CL/P患儿的死亡原因无差异，但最常见的死亡原因是综合征性CL/P的心血管异常。
据报道，每1000名婴儿中有1.96名婴儿是全球患病率最高的国家之一。CL/P儿童早产风险高，死亡风险高。最常见的死亡原因是心血管异常。
这项基于全国人群的队列研究评估了韩国所有5747830例活产，包括CL/P婴儿，从2006年到2018年。流行趋势分析，早产的风险，有或没有相关综合征的CL/P的死亡率和死亡原因(非综合征，综合征CL/P）和亚组（仅唇裂，只有腭裂,唇腭裂）进行评估。
在5747830例活产中，在研究期间，有11284名儿童被确定为患有CL/P。年患病率为每1000名新生儿1.96名。患病率，这显示了这一时期的趋势，是1.021。与非综合征性和综合征性CL/P儿童相比，非综合征性和综合征性CL/P儿童的早产风险更高（比值比：非综合征性1.43，综合征性5.29）。无CL/P儿童的每1000人年死亡率为0.39，非综合征性CL/P儿童为0.98，综合征性CL/P儿童为12.20。非综合征性CL/P患儿的死亡原因无差异，但最常见的死亡原因是综合征性CL/P的心血管异常。
据报道，每1000名婴儿中有1.96名婴儿是全球患病率最高的国家之一。CL/P儿童早产风险高，死亡风险高。最常见的死亡原因是心血管异常。
