We aimed to assess potential associations between respiratory mortality and residential proximity to (intensive) livestock farming.
In DUELS, a national census-based cohort, we selected all inhabitants from rural and semi-urban areas of the Netherlands, aged ≥30 years and living at the same address for five years up to baseline (2004). We followed these ∼4 million individuals for respiratory mortality (respiratory system diseases, chronic lower respiratory diseases, pneumonia) from 2005 to 2012. We computed the average number of cattle, pigs, chicken, and mink present in 500 m, 1000 m, 1500 m and 2000 m of each individual\'s residence in the period 1999-2003. Analyses were conducted using Cox proportional hazards regression, adjusting for potential confounders at individual and neighbourhood level.
We found evidence that living up to 2000 m of pig farms was associated with respiratory mortality, namely from chronic lower respiratory diseases, with Hazard Ratios ranging from 1.06 (1.02, 1.10) in people living close to low numbers (
我们的目的是评估呼吸道死亡率与居民接近(密集)畜牧业之间的潜在关联。
在DUELS中,基于全国人口普查的队列,我们选择了所有来自荷兰农村和半城市地区的居民,年龄≥30岁,在同一地址居住五年,直至基线(2004年)。我们追踪了这400万个人的呼吸系统死亡率(呼吸系统疾病,慢性下呼吸道疾病,肺炎)从2005年到2012年。我们计算了牛的平均数量,猪,鸡肉,和水貂存在于500米,1000米,在1999-2003年期间,每个人的住所为1500米和2000米。使用Cox比例风险回归进行分析,在个人和社区层面调整潜在的混杂因素。
我们发现有证据表明,活到2000米的养猪场与呼吸道死亡有关,即慢性下呼吸道疾病,在1000m猪数量接近低(<动物数量中位数)的人群中,危害比范围为1.06(1.02,1.10),在2000m猪数量接近高(≥中位数)的人群中,危害比范围为1.18(1.13,1.24)。我们还发现了生活在水貂养殖场附近的人群中肺炎死亡率较高的迹象。
我们的研究结果与之前关于禽畜养殖场附近居民呼吸不良影响的研究结果是一致的。人们对身体知之甚少,化学,以及导致呼吸道发病率和死亡率的生物暴露,有必要进一步探索牲畜养殖场附近的空气污染物。