PDF(Pubmed)
Abstract：
Gastrointestinal stromal tumors (GISTs) are rare tumors of the gastrointestinal tract accounting for less than 1% of all gut tumors. GISTs occurring in the rectum are extremely rare and these usually present at an advanced stage compared with other sites. We report a case of a middle-aged female who presented with features of anemia and subacute obstruction due to a large rectal tumor and underwent abdominoperineal resection. The histopathological examination confirmed the diagnosis of high-grade malignant GIST with multiple lymph nodal metastasis. She was started on adjuvant imatinib therapy and is on follow-up without any evidence of recurrence. The authors conclude that GIST must be included in the differential diagnosis of a rectal tumor. Diagnosis is established by biopsy and immunohistochemistry studies. Surgical resection with histological negative margins is the standard curative treatment. Adjuvant targeted therapy can reduce long-term recurrence in high-risk cases.
摘要：
胃肠道间质瘤(GIST)是罕见的胃肠道肿瘤,占所有肠道肿瘤的不到1%。发生在直肠中的GIST极为罕见，与其他部位相比，这些通常存在于晚期。我们报告了一例中年女性，由于直肠大肿瘤而表现出贫血和亚急性梗阻的特征，并接受了腹部手术切除。组织病理学检查证实诊断为高度恶性GIST伴多发淋巴结转移。她开始接受伊马替尼辅助治疗，并且正在随访中，没有任何复发的证据。作者得出结论，GIST必须包括在直肠肿瘤的鉴别诊断中。通过活检和免疫组织化学研究确定诊断。具有组织学阴性切缘的手术切除是标准的治愈性治疗。辅助靶向治疗可以减少高危病例的长期复发。
