{Reference Type}: Case Reports
{Title}: Malignant Gastrointestinal Stromal Tumor of Rectum: A Case Report and Review of Literature.
{Author}: Karthikeyan M;Kolandasamy C;Naganath Babu OL;Karthikeyan M;Kolandasamy C;Naganath Babu OL;
{Journal}: Surg J (N Y)
{Volume}: 8
{Issue}: 1
{Year}: Jan 2022
暂无{DOI}: 10.1055/s-0042-1742778
{Abstract}: Gastrointestinal stromal tumors (GISTs) are rare tumors of the gastrointestinal tract accounting for less than 1% of all gut tumors. GISTs occurring in the rectum are extremely rare and these usually present at an advanced stage compared with other sites. We report a case of a middle-aged female who presented with features of anemia and subacute obstruction due to a large rectal tumor and underwent abdominoperineal resection. The histopathological examination confirmed the diagnosis of high-grade malignant GIST with multiple lymph nodal metastasis. She was started on adjuvant imatinib therapy and is on follow-up without any evidence of recurrence. The authors conclude that GIST must be included in the differential diagnosis of a rectal tumor. Diagnosis is established by biopsy and immunohistochemistry studies. Surgical resection with histological negative margins is the standard curative treatment. Adjuvant targeted therapy can reduce long-term recurrence in high-risk cases.