PDF(Pubmed)
Abstract：
Chronic wounds (e.g. diabetic wounds, pressure wounds, vascular ulcers, etc.) do not usually heal in a timely and orderly manner but rather last for years and may lead to irreversible adverse events, resulting in a substantial financial burden for patients and society. Recently, a large amount of evidence has proven that cellular senescence has a crucial influence on chronic nonhealing wounds. As a defensive mechanism, cell senescence is a manner of cell-cycle arrest with increased secretory phenotype to resist death, preventing cells from stress-induced damage in cancer and noncancer diseases. A growing amount of research has advanced the perception of cell senescence in various chronic wounds and focuses on pathological and physiological processes and therapies targeting senescent cells. However, previous reviews have failed to sum up novel understandings of senescence in chronic wounds and emerging strategies targeting senescence. Herein, we discuss the characteristics and mechanisms of cellular senescence and the link between senescence and chronic wounds as well as some novel antisenescence strategies targeting other diseases that may be applied for chronic wounds.
摘要：
慢性伤口（例如糖尿病伤口，压力伤口,血管溃疡,等。)通常不会及时有序地愈合，而是持续数年，并可能导致不可逆转的不良事件，给患者和社会带来了巨大的经济负担。最近,大量的证据已经证明细胞衰老对慢性不愈合的伤口有至关重要的影响。作为一种防御机制，细胞衰老是细胞周期停滞的一种方式，分泌表型增加以抵抗死亡，防止细胞在癌症和非癌症疾病中受到应激诱导的损伤。越来越多的研究促进了各种慢性伤口中细胞衰老的感知，并专注于病理和生理过程以及靶向衰老细胞的疗法。然而,以前的综述未能总结对慢性伤口衰老的新理解和针对衰老的新兴策略。在这里，我们讨论了细胞衰老的特征和机制，衰老与慢性伤口之间的联系，以及一些针对其他疾病的新型抗衰老策略，这些策略可能适用于慢性伤口。
