PDF(Pubmed)
Abstract：
Dietary supplements sourced from marine environments, such as fish oils and seaweed-based supplements, are widely consumed to boost nutrient intakes, including by vulnerable populations such as pregnant women. Like other marine foods, these supplements are also a potential source of exposure to arsenic, including the known toxic species, inorganic arsenic, and the cytotoxic, lipid-soluble arsenic compounds, arsenic hydrocarbons. A study of 32 marine-sourced supplements found higher total arsenic concentrations (>1000 ng g-1) in supplements made from seaweed, krill and calanus oil, and in fish and fish liver products marketed as \"unprocessed\". Inorganic arsenic was only detectable in the seaweed samples, and was elevated (8900 ng g-1) in one product. Arsenic hydrocarbons were not detected in krill oil samples but were present at concentrations from 169 to 2048 ng g-1 in \"unprocessed\" fish and fish liver oil, and calanus oil. Survey data from the New Hampshire Birth Cohort Study (NHBCS) found 13.5% of pregnant women (n = 1997) reported taking fish oil supplements; and of those, most did so daily (75.6%, 6 or more times per week). Only a small percentage (9%) of those who reported consuming fish oil used products associated with higher arsenic levels. Higher urinary arsenic concentrations were found among women who consumed fish oil compared with those who did not, and specifically higher arsenobetaine and dimethyl arsenic concentrations. Dietary supplements are becoming common components of modern diets, and some marine-sourced dietary supplements are a source of inorganic arsenic and arsenic hydrocarbons.
摘要：
来自海洋环境的膳食补充剂，如鱼油和海藻补充剂，被广泛消耗以增加营养摄入量，包括孕妇等弱势群体。像其他海洋食物一样，这些补充剂也是接触砷的潜在来源，包括已知的有毒物种，无机砷,和细胞毒性，脂溶性砷化合物，砷碳氢化合物。一项对32种海洋来源补充剂的研究发现，海藻制成的补充剂中总砷浓度更高（>1000ngg-1），磷虾油和calanus油，以及以“未加工”销售的鱼和鱼肝产品。无机砷仅在海藻样品中检测到，并且在一种产品中升高（8900ngg-1）。磷虾油样品中未检测到砷烃，但在“未加工的”鱼和鱼肝油中以169至2048ngg-1的浓度存在，和calanus油。新罕布什尔州出生队列研究（NHBCS）的调查数据发现，有13.5％的孕妇（n=1997）报告服用鱼油补充剂；其中，大多数人每天都这样做(75.6%，每周6次或更多次)。报告食用鱼油的人中只有一小部分（9％）使用与较高砷含量相关的产品。与不食用鱼油的妇女相比，食用鱼油的妇女的尿砷浓度更高，特别是更高的砷甜菜碱和二甲基砷浓度。膳食补充剂正在成为现代饮食的常见组成部分，一些海洋来源的膳食补充剂是无机砷和砷碳氢化合物的来源。
