Abstract：
While type 2 immunity has traditionally been associated with the control of parasitic infections and allergic reactions, increasing evidence suggests that type 2 immunity exerts regulatory functions on inflammatory diseases such as arthritis, and also on bone homeostasis. This review summarizes the current evidence of the regulatory role of type 2 immunity in arthritis and bone. Key type 2 cytokines, like interleukin (IL)-4 and IL-13, but also others such as IL-5, IL-9, IL-25, and IL-33, exert regulatory properties on arthritis, dampening inflammation and inducing resolution of joint swelling. Furthermore, these cytokines share anti-osteoclastogenic properties and thereby reduce bone resorption and protect bone. Cellular effectors of this action are both T cells (i.e., Th2 and Th9 cells), but also non-T cells, like type 2 innate lymphoid cells (ILC2). Key regulatory actions mediated by type 2 cytokines and immune cells on both inflammation as well as bone homeostasis are discussed.
摘要：
虽然2型免疫传统上与控制寄生虫感染和过敏反应有关，越来越多的证据表明，2型免疫对炎性疾病如关节炎发挥调节功能，以及骨骼稳态。这篇综述总结了目前关于2型免疫在关节炎和骨骼中的调节作用的证据。关键的2型细胞因子，如白细胞介素（IL）-4和IL-13，还有其他如IL-5，IL-9，IL-25和IL-33，对关节炎发挥调节特性，抑制炎症和诱导关节肿胀的解决。此外，这些细胞因子具有抗破骨细胞的特性，从而减少骨吸收并保护骨。这种作用的细胞效应子都是T细胞(即，Th2和Th9细胞），还有非T细胞，如2型先天淋巴样细胞（ILC2）。讨论了2型细胞因子和免疫细胞对炎症和骨稳态的关键调节作用。
