METHODS: This study was provided according to the recommendations of the preferred reporting items for systematic reviews and meta-analyses statement. A comprehensive systematic search of online databases was performed to find eligible studies up to December 2020. The quality of studies was methodologically assessed using Newcastle-Ottawa Scale score.
RESULTS: We identified eight articles regarding MS brain lesions and SD through the search strategy. Seven studies showed significant associations between SD and brain lesions. Three studies investigated the brain stem, two studies the insular and occipital region, one study the frontal lobe, prefrontal cortex, and temporal lobe and one study the parietal area.
CONCLUSIONS: The results of this systematic review showed that lesions in different brain areas are correlated with SD in MS patients. Plaques in the occipital and hippocampus areas, as well as left insula appear to be related to dysfunction of sexual arousability or lubrication/erection in MS patients. Orgasmic dysfunction in MS patients may be associated with brain lesions in pons, left temporal periventricular, and right occipital areas.
方法:本研究是根据系统评价和荟萃分析陈述的首选报告项目的建议提供的。对在线数据库进行了全面系统的搜索,以找到截至2020年12月的合格研究。使用纽卡斯尔-渥太华量表评分对研究质量进行方法学评估。
结果:我们通过搜索策略确定了8篇关于MS脑部病变和SD的文章。七项研究表明,SD与脑部病变之间存在显着关联。三项研究调查了脑干,两项研究是岛叶和枕骨区域,一项研究额叶,前额叶皮质,颞叶和一个研究顶叶区域。
结论:这项系统评价的结果表明,MS患者不同脑区的病变与SD相关。枕骨和海马区的斑块,以及左岛似乎与MS患者的性唤起或润滑/勃起功能障碍有关。MS患者的性高潮功能障碍可能与脑桥的脑损伤有关,左颞室周围,和右枕骨区域。