Abstract：
Listeria monocytogenes causes listeriosis with a high mortality rate. This study systematically reviewed the antibiotic susceptibility of L. monocytogenes in the world. A literature search was done and the data of 33 studies that matched with the inclusion criteria, were used for meta-analysis. The random-effect model meta-analysis was applied to determine the frequency of overall L. monocytogenes and its antibiotic non-sensitive isolates. The frequency of L. monocytogenes contamination in non-human sources was 10.3%. The most frequent serotypes were 4b and 4ab in human and non-human isolates, respectively. The resistance of L. monocytogenes isolates to the first-line antibiotics namely penicillin, ampicillin/amoxicillin, gentamicin, and trimethoprim-sulfamethoxazole has been increased in recent years. Altogether, the results indicated a concern for the antibiotic resistance in L. monocytogenes isolates over time. The implement of the registry and surveillance systems is required to improve the insight of L. monocytogenes antibiotic susceptibility and its treatment choices.
摘要：
单核细胞增生李斯特菌引起李斯特菌病，死亡率高。本研究系统综述了国内外单核细胞增生李斯特菌对抗生素的敏感性。进行了文献检索，33项符合纳入标准的研究数据，用于荟萃分析。随机效应模型荟萃分析用于确定整体单核细胞增生李斯特菌及其抗生素非敏感分离株的频率。非人来源中单核细胞增生李斯特菌的污染频率为10.3％。在人和非人分离株中最常见的血清型是4b和4ab，分别。单核细胞增生李斯特菌对一线抗生素即青霉素的耐药性，氨苄青霉素/阿莫西林,庆大霉素,甲氧苄啶-磺胺甲恶唑近年来有所增加。总之,结果表明，随着时间的推移，单核细胞增生李斯特菌分离株的抗生素耐药性令人担忧。需要实施注册和监测系统以提高对单核细胞增生李斯特菌抗生素敏感性及其治疗选择的认识。
