伊马替尼和醋甲唑胺通过提高 ACE2 酶活性和抑制病毒进入改善 COVID - 19 诱导的代谢并发症。
关键词: ACE2 COVID-19 SARS-CoV-2 enzymatic activator harpagoside imatinib metabolic complication methazolamide
Mesh : Angiotensin-Converting Enzyme 2 / drug effects metabolism Animals COVID-19 / complications metabolism virology Cells, Cultured Chlorocebus aethiops Down-Regulation / drug effects HEK293 Cells Human Umbilical Vein Endothelial Cells Humans Imatinib Mesylate / pharmacology therapeutic use Male Metabolic Diseases / drug therapy metabolism virology Methazolamide / pharmacology therapeutic use Mice Mice, Inbred C57BL Mice, Obese Mice, Transgenic SARS-CoV-2 / drug effects physiology Vero Cells Virus Internalization / drug effects COVID-19 Drug Treatment
来 源: DOI:10.1016/j.cmet.2022.01.008