关键词: cancer chemotherapy cryopreservation embryos fertility preservation oocytes safety

Mesh : Cohort Studies Cryopreservation / methods Female Fertility Preservation / methods Humans Neoplasms Oocytes / physiology Ovulation Induction / adverse effects methods

来  源:   DOI:10.1177/17455065221074886

Abstract:
Review the safety of fertility preservation through ovarian stimulation with oocyte or embryo cryopreservation, including cycle and medication options.
A systematic review of peer-reviewed sources revealed 2 applicable randomized control trials and 60 cohort studies as well as 20 additional expert opinions or reviews.
The capacity for future family building is important for the majority of reproductive age people, despite life-altering medical or oncologic diagnosis. Modern fertility preservation generates a high rate of oocyte yield while utilizing protocols that can be started at multiple points in the menstrual cycle and suppressing supra-physiologic levels of estrogen. Finally, more than one quarter of fertility preservation patients will return to later utilize fertility services.
For most patients, fertility preservation can safely be pursued and completed within 2 weeks without affecting disease severity or long-term survival.
摘要:
回顾通过卵母细胞或胚胎冷冻保存通过卵巢刺激来保存生育力的安全性,包括周期和药物选择。
对同行评审来源的系统评价显示,有2项适用的随机对照试验和60项队列研究以及20项额外的专家意见或评价。
未来家庭建设的能力对大多数育龄人口来说很重要,尽管改变了生命的医学或肿瘤诊断。现代的生育力保存可产生高的卵母细胞产率,同时利用可以在月经周期的多个点开始并抑制雌激素的超生理水平的方案。最后,超过四分之一的保留生育的患者将在以后使用生育服务。
对于大多数患者来说,在不影响疾病严重程度或长期生存的情况下,可以安全地进行生育力保存并在2周内完成.
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