关键词: Cefazolin Cervical laminoplasty Complication Epidural hematoma Neuromuscular blockade Perioperative prophylactic antibiotics

Mesh : Anti-Bacterial Agents / therapeutic use Cervical Vertebrae / diagnostic imaging surgery Humans Laminoplasty / adverse effects methods Postoperative Complications / etiology surgery Quadriplegia / etiology surgery

来  源:   DOI:10.1007/s00701-022-05148-3

Abstract:
The use of antibiotics can, in rare cases, induce neuromuscular blockade (NMB), resulting in paralytic symptoms. Although such antibiotic-induced NMB has been described in the anaesthesiology and infectious disease literature, it is an unfamiliar clinical entity in the fields of neurosurgery and spinal surgery. Herein, we report a case of periodic quadriplegia due to NMB induced by perioperative prophylactic antibiotic of cefazolin, resulting in highly confusing paralytic symptoms during the acute postoperative phase of cervical laminoplasty, together with a review of the relevant literature.
摘要:
使用抗生素可以,在极少数情况下,诱导神经肌肉阻滞(NMB),导致瘫痪症状。尽管在麻醉学和传染病文献中已经描述了这种抗生素诱导的NMB,在神经外科和脊柱外科领域,它是一个陌生的临床实体。在这里,我们报告了一例围手术期预防性抗生素头孢唑林引起的NMB引起的周期性四肢瘫痪,在颈椎椎板成形术的急性术后阶段导致高度混乱的麻痹症状,并对相关文献进行了回顾。
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