Abstract：
Bone disorders have become a global concern illustrated with decreased bone mineral density and disruption in microarchitecture of natural bone tissue organization. Natural compounds that promote bone health by augmenting osteoblast functions and suppressing osteoclast functions has gained much attention and offer greater therapeutic value compared to conventional therapies. Amongst several plant-based molecules, flavonoids act as a major combatant in promoting bone health through their multi-faceted biological activities such as antioxidant, anti-inflammatory, and osteogenic properties. They protect bone loss by regulating the signalling cascades involved in osteoblast and osteoclast functions. Flavonoids augment osteoblastogenesis and inhibits osteoclastogenesis through their modulation of various signalling pathways. This review discusses the role of various flavonoids and their molecular mechanisms involved in maintaining bone health by regulating osteoblast and osteoclast functions.
摘要：
骨疾病已成为全球关注的问题，说明骨矿物质密度降低和天然骨组织微观结构的破坏。与常规疗法相比,通过增强成骨细胞功能和抑制破骨细胞功能来促进骨健康的天然化合物获得了很多关注并提供了更大的治疗价值。在几种基于植物的分子中，类黄酮作为一个主要的战斗在促进骨骼健康通过其多方面的生物活性，如抗氧化剂，抗炎,和成骨特性。它们通过调节参与成骨细胞和破骨细胞功能的信号级联来保护骨损失。类黄酮通过其对各种信号通路的调节来增强成骨细胞生成并抑制破骨细胞生成。本文综述了各种黄酮类化合物在通过调节成骨细胞和破骨细胞功能维持骨骼健康中的作用及其分子机制。
