Abstract：
This is the first report on the simple preparation of gold nanoclusters stabilized with pregabalin (PREG) as a capping and reducing agent. PREG is an active pharmaceutical ingredient of the commercially available drug \"Lyrica\" used to treat different diseases like epilepsy and anxiety. PREG has never been used before in the synthesis of any nanoparticles or nanoclusters. The prepared gold nanoclusters (PREG-stabilized gold nanoclusters [PREG-AuNCs]) have blue fluorescence with excitation/emission at 365/425 nm, respectively. The reaction conditions were optimized for the synthesis of the as-prepared AuNCs. Different tools were used for the characterization of the synthesized nanoclusters in terms of size and surface properties. The PREG-AuNCs were exploited as a sensitive and selective fluorescent nanosensor for Cu2+ detection. The quenching of AuNC fluorescence intensity in the presence of Cu2+ is due to the aggregation-induced fluorescence quenching mechanism. The detection limit of Cu2+ ions was found to be 1.11 × 10-7 M. The selectivity of the PREG-AuNCs was studied and proved to be excellent. The drug entrapment efficacy and in vitro drug diffusion studies along with drug release kinetics helped to understand more about the pharmaceutical approaches of PREG-AuNCs. Moreover, we think that PREG-AuNCs open new opportunities as a promising candidate material for drug delivery systems and medical applications.
摘要：
这是关于用普瑞巴林(PREG)作为封端和还原剂稳定的金纳米团簇的简单制备的第一份报告。PREG是市售药物“Lyrica”的活性药物成分，用于治疗癫痫和焦虑症等不同疾病。PREG以前从未用于合成任何纳米颗粒或纳米簇。制备的金纳米簇（PREG稳定的金纳米簇[PREG-AuNC]）具有蓝色荧光，在365/425nm处激发/发射，分别。优化了反应条件以合成所制备的AuNC。不同的工具用于在尺寸和表面性质方面表征合成的纳米团簇。PREG-AuNC被用作用于Cu2检测的灵敏和选择性荧光纳米传感器。Cu2+存在下AuNC荧光强度的猝灭是由于聚集诱导的荧光猝灭机制。发现Cu2离子的检出限为1.11×10-7M。研究了PREG-AuNC的选择性，并证明了该选择性。药物包封功效和体外药物扩散研究以及药物释放动力学有助于更多地了解PREG-AuNC的药物方法。此外，我们认为PREG-AuNC为药物输送系统和医疗应用开辟了新的机会。
