Abstract：
Negative symptoms (NS) severely affect daily functioning already at the psychosis onset. However, most studies investigating beneficial effects of specific treatments for NS mainly included individuals with prolonged psychotic disorders. Furthermore, evidence on psychosocial rehabilitation for NS in early psychosis is still relatively poor. The aims of this study therefore were (A) to longitudinally examine NS stability in people with first episode psychosis (FEP) along a 2-year follow-up period, and (B) to overtime explore any relevant association of NS levels with the specific intervention components of an \'early intervention in psychosis\' (EIP) protocol during the follow-up.
At baseline, 266 FEP subjects (aged 12-35 years) completed the positive and negative syndrome scale (PANSS). Multiple linear regression analyses were then performed.
Along the follow-up, FEP participants had a relevant improvement in NS levels. This was specifically predicted by the total number of case management sessions offered within our 2-year EIP protocol, as well as by shorter duration of untreated psychosis at entry and by longitudinal reduction in PANSS depressive and positive symptom dimension levels. No association with antipsychotic medication was found.
NS are clinically relevant in FEP, already at the recruitment time in specialized EIP services. However, their severity appears to improve over time together with the delivery of patient-tailored, integrated EIP case management.
At baseline, 266 FEP subjects (aged 12-35 years) completed the positive and negative syndrome scale (PANSS). Multiple linear regression analyses were then performed.
Along the follow-up, FEP participants had a relevant improvement in NS levels. This was specifically predicted by the total number of case management sessions offered within our 2-year EIP protocol, as well as by shorter duration of untreated psychosis at entry and by longitudinal reduction in PANSS depressive and positive symptom dimension levels. No association with antipsychotic medication was found.
NS are clinically relevant in FEP, already at the recruitment time in specialized EIP services. However, their severity appears to improve over time together with the delivery of patient-tailored, integrated EIP case management.
摘要：
阴性症状（NS）严重影响精神病发作时的日常功能。然而,大多数研究NS特定治疗方法的有益效果的研究主要包括患有长期精神病的个体。此外，关于早期精神病患者NS的心理社会康复的证据仍然相对不足。因此，本研究的目的是（A）在2年的随访期内纵向检查首发精神病（FEP）患者的NS稳定性，和（B）在随访期间，探索NS水平与“精神病早期干预”（EIP）方案的特定干预组成部分之间的任何相关关联。
在基线，266名FEP受试者(年纪12-35岁)完成阳性和阴性综合征量表(PANSS)。然后进行多元线性回归分析。
在后续行动中，FEP参与者的NS水平有相关改善。这是由我们为期2年的EIP协议中提供的病例管理会议总数特别预测的，以及进入时未经治疗的精神病持续时间较短，以及PANSS抑郁和阳性症状维度水平的纵向降低。未发现与抗精神病药物有关。
NS在FEP中具有临床相关性，已经在专业EIP服务的招聘时间。然而,随着时间的推移，它们的严重程度似乎会随着患者量身定制的交付而改善，集成的EIP案例管理。
在基线，266名FEP受试者(年纪12-35岁)完成阳性和阴性综合征量表(PANSS)。然后进行多元线性回归分析。
在后续行动中，FEP参与者的NS水平有相关改善。这是由我们为期2年的EIP协议中提供的病例管理会议总数特别预测的，以及进入时未经治疗的精神病持续时间较短，以及PANSS抑郁和阳性症状维度水平的纵向降低。未发现与抗精神病药物有关。
NS在FEP中具有临床相关性，已经在专业EIP服务的招聘时间。然而,随着时间的推移，它们的严重程度似乎会随着患者量身定制的交付而改善，集成的EIP案例管理。
