Abstract：
The objective of the present study was to evaluate the effects of a tributyrin and monolaurin blend compared to high ZnO levels in weaned piglets under field conditions. In Trial 1, piglets (n = 168) were assigned to 1 of 2 treatments: 1) control (CON; diet supplemented with 3000 g ZnO/t of feed; n = 8 replicates); 2) tributyrin and monolaurin blend - Porcestin™ (PR; diet supplemented with basal level of ZnO at 150 g/t and with the tested blend at 5 kg/t of feed; n = 8 replicates). In Trial 2, piglets (n = 244) were assigned to the same two treatments (n = 10 replicates). The study duration was 4 (Trial 1) and 6 (Trial 2) weeks post-weaning. In both trials, growth performance was similar between treatments (P > 0.05). In Trial 1, faecal counts of Lactobacillus spp. increased in pigs of PR group (P < 0.05). In both trials, histomorphometrical analysis of jejunum and ileum samples showed a thicker intestinal mucosa in favor of the PR treatment (P < 0.01), and Foxp3-positive regulatory T cells increased together with a concomitant decrease of MPO-positive granulocytes in jejunal mucosa of piglets from the PR treatment (P < 0.01). Overall, supplementation of monolaurin and tributyrin blend compared to high ZnO levels resulted in similar growth performance. Moreover, beneficial effects on small intestinal morphometry and immune cells responses indicate its ability to attenuate inflammatory processes. Further research is necessary to optimize the use of tested product.
摘要：
本研究的目的是评估在田间条件下断奶仔猪中三丁酸甘油酯和单月桂酸酯共混物与高ZnO含量相比的效果。在试验1中，将仔猪（n=168）分配到2种处理中的1种：1）对照（CON；饮食中补充了3000gZnO/t饲料；n=8个重复）；2）三丁酸甘油酯和单月桂酸甘油酯混合物-Porcestin™（PR；饮食中补充了150g/t的ZnO基础水平，并以5kg/t的饲料补充了测试混合物；n=8个重复）在试验2中,将仔猪(n=244)分配到相同的两个处理(n=10个重复)。研究持续时间为断奶后4周(试验1)和6周(试验2)。在两个试验中,各处理间生长性能相似(P>0.05)。在试验1中，乳杆菌属的粪便计数。猪PR组增加(P<0.05)。在两个试验中,空肠和回肠的组织形态计量学分析显示，肠粘膜较厚，有利于PR治疗（P<0.01），PR处理后仔猪空肠粘膜中Foxp3阳性调节性T细胞增加，MPO阳性粒细胞减少（P<0.01）。总的来说,与高ZnO水平相比，补充单月桂酸和三丁酸甘油酯混合物会导致相似的生长性能。此外，对小肠形态计量学和免疫细胞反应的有益作用表明其减弱炎症过程的能力。需要进一步研究以优化测试产品的使用。
