Abstract：
OBJECTIVE: To present a case of Sjogren syndrome with pulmonary manifestations in an adult female and discuss its assessment and management.
METHODS: Case Report.
METHODS: Tertiary care hospital.
METHODS: One.
RESULTS: A 50 yrs female admitted with complaints of dryness of eyes with decreased salivation causing difficulty in swallowing since last 3 years, with persistent dry cough since 10-15 days and progressive dyspnea since 4-5 days. Anti-nuclear antibody (ANA) profile revealed Anti- Ro/SS-A and Anti- La/SS-B Positive. Also, sub-lingual excisional biopsy was done which was consistent with findings of Sjogren\'s syndrome. Patient showed significant improvement after starting oral glucocorticoids, systemic anti inflammatory agents (Tab. HCQS), artificial tear drops, oral iron supplements and other supportive treatment.
CONCLUSIONS: Sjögren syndrome (SS) is a chronic inflammatory disorder characterized by diminished lacrimal and salivary gland function and associated with lymphocytic infiltration of exocrine glands, and can affect extraglandular organ systems including the skin, lung, heart, kidney, neural, and hematopoietic systems. We present a case of Sjogren syndrome in an adult female presenting with xerostomia and dyspnea and was diagnosed upon detection of anti-Ro and anti-La antibodies and confirmed by histopathological examination of lip biopsy. Patient was started on oral steroids and other supportive treatment, General condition improved significantly and is doing very well on regular follow-up.
METHODS: Case Report.
METHODS: Tertiary care hospital.
METHODS: One.
RESULTS: A 50 yrs female admitted with complaints of dryness of eyes with decreased salivation causing difficulty in swallowing since last 3 years, with persistent dry cough since 10-15 days and progressive dyspnea since 4-5 days. Anti-nuclear antibody (ANA) profile revealed Anti- Ro/SS-A and Anti- La/SS-B Positive. Also, sub-lingual excisional biopsy was done which was consistent with findings of Sjogren\'s syndrome. Patient showed significant improvement after starting oral glucocorticoids, systemic anti inflammatory agents (Tab. HCQS), artificial tear drops, oral iron supplements and other supportive treatment.
CONCLUSIONS: Sjögren syndrome (SS) is a chronic inflammatory disorder characterized by diminished lacrimal and salivary gland function and associated with lymphocytic infiltration of exocrine glands, and can affect extraglandular organ systems including the skin, lung, heart, kidney, neural, and hematopoietic systems. We present a case of Sjogren syndrome in an adult female presenting with xerostomia and dyspnea and was diagnosed upon detection of anti-Ro and anti-La antibodies and confirmed by histopathological examination of lip biopsy. Patient was started on oral steroids and other supportive treatment, General condition improved significantly and is doing very well on regular follow-up.
摘要：
目的：介绍一例成年女性合并肺部症状的干燥综合征，并讨论其评估和治疗方法。
方法：病例报告。
方法：三级医院。
方法：一种。
结果：自过去3年以来，一名50岁的女性因眼睛干燥而流涎减少，导致吞咽困难，持续干咳10-15天，进行性呼吸困难4-5天。抗核抗体(ANA)谱显示抗Ro/SS-A和抗La/SS-B阳性。此外，舌下切除活检与干燥综合征的发现一致。患者开始口服糖皮质激素后表现出显著改善，全身性抗炎药（Tab.HCQS)，人工泪滴，口服铁补充剂和其他支持治疗。
结论：干燥综合征（SS）是一种慢性炎症性疾病，其特征是泪腺和唾液腺功能减弱，并伴有外分泌腺的淋巴细胞浸润，会影响包括皮肤在内的外胎器官系统，肺，心,肾,神经,和造血系统。我们介绍了一例患有口干症和呼吸困难的成年女性干燥综合征，并在检测到抗Ro和抗La抗体后被诊断出来，并通过嘴唇活检的组织病理学检查得到证实。患者开始口服类固醇和其他支持治疗，一般情况明显改善，并且在定期随访中表现良好。
方法：病例报告。
方法：三级医院。
方法：一种。
结果：自过去3年以来，一名50岁的女性因眼睛干燥而流涎减少，导致吞咽困难，持续干咳10-15天，进行性呼吸困难4-5天。抗核抗体(ANA)谱显示抗Ro/SS-A和抗La/SS-B阳性。此外，舌下切除活检与干燥综合征的发现一致。患者开始口服糖皮质激素后表现出显著改善，全身性抗炎药（Tab.HCQS)，人工泪滴，口服铁补充剂和其他支持治疗。
结论：干燥综合征（SS）是一种慢性炎症性疾病，其特征是泪腺和唾液腺功能减弱，并伴有外分泌腺的淋巴细胞浸润，会影响包括皮肤在内的外胎器官系统，肺，心,肾,神经,和造血系统。我们介绍了一例患有口干症和呼吸困难的成年女性干燥综合征，并在检测到抗Ro和抗La抗体后被诊断出来，并通过嘴唇活检的组织病理学检查得到证实。患者开始口服类固醇和其他支持治疗，一般情况明显改善，并且在定期随访中表现良好。
