Abstract：
Aspergillus calidoustus is an emerging, azole-resistant, cryptic Aspergillus species in immunosuppressed patients that often features extrapulmonary involvement and carries high mortality. The case presented by J. F. Camargo, R. Jabr, A. D. Anderson, L. Lekakis, et al. (Antimicrob Agents Chemother 66:e02206-21, 2022, https://doi.org/10.1128/aac.02206-21) describes a transplant recipient with disseminated A. calidoustus infection who was successfully treated with surgical source control, tapering of immunosuppression, and long-term, combination antifungal treatment that included the first-in-class fosmanogepix, which targets fungal mannoprotein trafficking and anchoring.
摘要：
钙曲霉是一种新兴的，耐唑，免疫抑制患者中的隐性曲霉属，通常具有肺外受累和高死亡率。J.F.Camargo提出的案件,R.Jabr,A.D.安德森，L.Lekakis,etal.（AntimicrobAgentsChemother66：e02206-21，2022，https://doi.org/10.1128/aac.02206-21）描述了患有播散性A.calidoustus感染的移植受者，通过手术源控制成功治疗，逐渐减少免疫抑制，从长远来看，联合抗真菌治疗，包括一流的fosmanogepix，针对真菌甘露糖蛋白的运输和锚定。
