PDF(Pubmed)
Abstract：
Endothelial nitric oxide synthase (eNOS) plays a critical role in regulating and maintaining a healthy cardiovascular system. The importance of eNOS can be emphasized from the genetic polymorphisms of the eNOS gene, uncoupling of eNOS dimerization, and its numerous signaling regulations. The activity of eNOS on the cardiac myocytes, vasculature, and the central nervous system are discussed. The effects of eNOS on the sympathetic autonomic nervous system (SANS) and the parasympathetic autonomic nervous system (PANS), both of which profoundly influence the cardiovascular system, will be elaborated. The relationship between the eNOS protein with cardiovascular autonomic reflexes such as the baroreflex and the Exercise Pressor Reflex will be discussed. For example, the effects of endogenous nitric oxide (NO) are shown to be mediated by the eNOS protein and that eNOS-derived endothelial NO is most effective in regulating blood pressure oscillations via modulating the baroreflex mechanisms. The protective action of eNOS on the CVS is emphasized here because dysfunction of the eNOS enzyme is intricately correlated with the pathogenesis of several cardiovascular diseases such as hypertension, arteriosclerosis, myocardial infarction, and stroke. Overall, our current understanding of the eNOS protein with a focus on its role in the modulation, regulation, and control of the cardiovascular system in a normal physiological state and in cardiovascular diseases are discussed.
摘要：
内皮型一氧化氮合酶（eNOS）在调节和维持健康的心血管系统中起着至关重要的作用。eNOS的重要性可以从eNOS基因的遗传多态性来强调,eNOS二聚化的解偶联，及其众多的信号法规。eNOS对心肌细胞的活性，脉管系统,讨论了中枢神经系统。eNOS对交感神经自主神经系统（SANS）和副交感神经自主神经系统（PANS）的影响，两者都对心血管系统产生了深远的影响，将详细阐述。将讨论eNOS蛋白与心血管自主神经反射之间的关系，例如压力反射和运动压力反射。例如,内源性一氧化氮（NO）的作用被证明是由eNOS蛋白介导的，并且eNOS衍生的内皮NO通过调节压力反射机制在调节血压波动中最有效。这里强调eNOS对CVS的保护作用，因为eNOS酶的功能障碍与高血压等多种心血管疾病的发病机理密切相关。动脉硬化,心肌梗塞,和中风。总的来说,我们目前对eNOS蛋白的理解集中在其在调制中的作用，regulation,讨论了在正常生理状态和心血管疾病中对心血管系统的控制。
