PDF(Pubmed)
Abstract：
Gastric carcinoma is one of the most common types of cancer worldwide and a leading cause of cancer-related mortality. Gastric carcinoma is histologically subdivided into differentiated and undifferentiated carcinoma, with the latter including poorly differentiated carcinoma and signet ring cell carcinoma (SRCC). Poorly differentiated carcinoma and SRCC have a worse prognosis compared with differentiated carcinoma. Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors and the PPAR-α subtype regulates important cellular functions, including cell proliferation, energy metabolism, oxidative stress, immune responses and cell differentiation. The aim of the present study was to elucidate the associations between clinicopathological factors and PPAR-α expression in patients with gastric carcinoma. The immunohistochemical staining of specimens obtained from 57 patients showed that PPAR-α expression was slightly weaker in undifferentiated carcinoma than in differentiated carcinoma (P<0.01). PPAR-α expression also significantly differed between poorly differentiated carcinoma (both positive and negative: 14/20, 70%) and SRCC (not expressed: 0/7, 0%) (P<0.01). However, PPAR-α expression was not significantly affected by age, lymph node invasion, venous invasion, lymph node metastasis, depth of invasion or stage. Collectively, the present results demonstrated that the downregulated expression of PPAR-α may play a key role in the biological transformation of tumors. Therefore, PPAR-α appears to be an important protein related to histology and may hold promise as a prognostic marker. Further studies with a larger number of subjects are needed to elucidate the relationship between PPAR-α expression and tumor progression and to analyze long-term clinical survival.
摘要：
胃癌是世界范围内最常见的癌症类型之一，也是癌症相关死亡的主要原因。胃癌在组织学上分为分化癌和未分化癌，后者包括低分化癌和印戒细胞癌（SRCC）。与分化癌相比，低分化癌和SRCC的预后较差。过氧化物酶体增殖物激活受体（PPAR）是核激素受体，PPAR-α亚型调节重要的细胞功能，包括细胞增殖，能量代谢，氧化应激，免疫反应和细胞分化。本研究的目的是阐明胃癌患者临床病理因素与PPAR-α表达之间的关系。对57例患者的标本进行免疫组织化学染色显示，未分化癌中PPAR-α的表达略弱于分化癌（P<0.01）。PPAR-α在低分化癌（阳性和阴性：14/20，70％）和SRCC（未表达：0/7，0％）之间也有显着差异（P<0.01）。然而,PPAR-α的表达不受年龄的影响,淋巴结浸润，静脉侵入,淋巴结转移,入侵深度或阶段。总的来说，本研究结果表明,PPAR-α的表达下调可能在肿瘤的生物转化中起关键作用。因此,PPAR-α似乎是与组织学相关的重要蛋白质，可能有望作为预后标志物。需要对更多受试者进行进一步研究，以阐明PPAR-α表达与肿瘤进展之间的关系，并分析长期临床生存率。
