Development of the gonadotropin-releasing hormone system.

促性腺激素释放激素系统的发育。

• 影响指数: 3.87
• 发表时间: 05 2022
• 来源期刊: J Neuroendocrinol
• DOI: 10.1111/jne.13087
• PMID: 35067985
• 文章类型: Journal Article
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Duittoz AH,Forni PE,Giacobini P,Golan M,Mollard P,Negrón AL,Radovick S,Wray S

关键词: GnRH; development; guidance cues; migratory pathway; olfactory ensheathing cells; olfactory placode; synaptic and paracrine signals; terminal nerve; transcription factors

Mesh: Female; Gene Expression Regulation; Gonadotropin-Releasing Hormone / metabolism; Humans; Neurons / metabolism; Neurosecretory Systems / metabolism; Pregnancy

Abstract

This review summarizes the current understanding of the development of the neuroendocrine gonadotropin-releasing hormone (GnRH) system, including discussion on open questions regarding (1) transcriptional regulation of the Gnrh1 gene; (2) prenatal development of the GnRH1 system in rodents and humans; and (3) paracrine and synaptic communication during migration of the GnRH cells.

摘要

这篇综述总结了目前对神经内分泌促性腺激素释放激素（GnRH）系统的发展的认识。包括有关以下方面的开放性问题的讨论：（1）Gnrh1基因的转录调控；（2）啮齿动物和人类GnRH1系统的产前发育；（3）GnRH细胞迁移过程中的旁分泌和突触通讯。