Abstract：
Fibrosis continues to challenge the regeneration and repair of the Orthopaedic tissues in states of injury or disease. The mechanism behind developmental fibrosis has been widely investigated in the last few decades. However, the current efficacy of treatment for existing fibrous scars remains insufficient from both basic research and clinical perspectives. Scarred fibrotic tissue impedes the physical function of affected local tissues and organs and may also be associated with abnormal pain conduction or tissue reinjury. It is necessary to discover the functional treatment for fibrous scars as this pathology is medically demanding to effected patients. The current article will review the mechanisms behind fibrosis formation and the treatment potential in the field of the musculoskeletal system, especially in the pathology and treatment of injured skeletal muscle and the development of osteoarthritis.
摘要：
纤维化继续在损伤或疾病状态下挑战骨科组织的再生和修复。在过去的几十年中，发育性纤维化背后的机制得到了广泛的研究。然而,从基础研究和临床角度来看，现有纤维性瘢痕的治疗效果仍然不足。瘢痕纤维化组织阻碍受影响的局部组织和器官的身体功能,并且还可能与异常疼痛传导或组织再损伤有关。有必要发现纤维性疤痕的功能性治疗，因为这种病理对受影响的患者在医学上要求很高。本文将回顾纤维化形成背后的机制和肌肉骨骼系统领域的治疗潜力，特别是在损伤的骨骼肌的病理和治疗以及骨关节炎的发展中。
