Abstract：
As with all drugs, the route, form, and/or dose of a substance administered or applied can play a defining role in its overall pharmacology and use as a therapeutic. This review will focus on these factors as they relate to the psychedelic N,N-dimethyltryptamine (DMT). It will examine the positive and negative aspects of different formulations and routes of administration of DMT and the observed effects from such administrations in the form of ayahuasca teas; oral \"pharmahuasca\"; injections by intravenous (IV) and intramuscular (IM) routes; inhalation, insufflation; and other routes; and high-dose, low-dose, and \"micro-dose\" effects. The review will consider possible oral route of administration alternatives that would not require concomitant use of a monoamine oxidase inhibitor. The review will then address the current research findings for DMT from in vivo and in vitro studies as well as the possibility that these findings may be revealing the role of endogenous DMT in normal brain function.
摘要：
和所有药物一样，路线,形式,和/或施用或施用的物质的剂量可以在其整体药理学和作为治疗剂的用途中起决定性作用。这篇综述将集中在这些与迷幻N相关的因素上，N-二甲基色胺(DMT)。它将检查DMT的不同制剂和给药途径的积极和消极方面，以及以ayahuasca茶的形式给药的观察到的效果；口服“harmahuasca”；通过静脉内（IV）和肌内（IM）途径注射；吸入，吹气；和其他途径；和高剂量，低剂量,和“微剂量”效应。该综述将考虑不需要同时使用单胺氧化酶抑制剂的可能的口服给药途径。然后，该综述将讨论来自体内和体外研究的DMT的当前研究结果，以及这些发现可能揭示内源性DMT在正常脑功能中的作用的可能性。
