Abstract：
Introduction: Acute pulmonary embolism (aPE) is frequently associated with coronavirus infectious disease-2019 (COVID-19) with an incidence of more than 16%. Among the new promising biomarkers of aPE, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) showed correlations with aPE prognosis. The aim of this study was to conduct an exploratory analysis to check the possible role of cell blood count (CBC) parameters as diagnostic and prognostic biomarkers of aPE in COVID-19 patients. Materials and Methods: A case control study was conducted. Two populations were compared: (i) patients hospitalised from 31 January 2020 to 30 June 2021 with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection and aPE confirmed at angio computed tomography (aCT) or pulmonary scintigraphy (COVID-19 aPE group); (ii) patients hospitalised from 31 January 2017 to 30 June 2021 without SARS-CoV-2 infection whose suspicion of aPE was excluded by aCT or pulmonary scintigraphy (no-aPE group). Results: Overall, 184 patients were included in the study, 83 in COVID-19 aPE group and 101 in no-aPE group. At the univariate analysis, COVID-19 patients with aPE had higher NLR, PLR, neutrophil and lymphocyte counts than patients without aPE (p < 0.05). No significant difference was found in mean platelet volume and platelet counts. No difference in mortality rate was detected. At the multivariate analysis, neutrophil and lymphocyte counts were both associated with diagnostic of aPE while no CBC parameters were associated with mortality at day#7. Conclusions: Neutrophiland lymphocyte counts could be predictors of the early detection of aPE in COVID-19 patients. The value of CBC indices as biomarkers of aPE in daily clinical practice needs to be investigated in further studies.
摘要：
简介：急性肺栓塞（aPE）经常与2019年冠状病毒传染病（COVID-19）相关，发病率超过16％。在aPE的新的有希望的生物标志物中，中性粒细胞/淋巴细胞比值(NLR)和血小板/淋巴细胞比值(PLR)与aPE预后相关.这项研究的目的是进行一项探索性分析，以检查细胞血细胞计数（CBC）参数作为COVID-19患者aPE的诊断和预后生物标志物的可能作用。材料与方法：采用病例对照研究。比较了两个人群：（i）从2020年1月31日至2021年6月30日因严重急性呼吸综合征-冠状病毒2（SARS-CoV-2）感染而住院的患者，并在血管计算机断层扫描（aCT）或肺闪烁显像（COVID-19aPE组）中证实了aPE；（ii）从2017年1月31日至2021年6月30日未因SARS-CoV-2感染而住院的患者结果：总体而言，184名患者被纳入研究，COVID-19aPE组83例，非aPE组101例。在单变量分析中，COVID-19aPE患者NLR较高，PLR,中性粒细胞和淋巴细胞计数高于无aPE患者(p<0.05)。在平均血小板体积和血小板计数方面没有发现显着差异。没有发现死亡率的差异。在多变量分析中，中性粒细胞和淋巴细胞计数均与aPE的诊断相关,而在第7天没有CBC参数与死亡率相关.结论：嗜中性粒细胞和淋巴细胞计数可能是COVID-19患者早期发现aPE的预测因子。CBC指数作为aPE的生物标志物在日常临床实践中的价值需要进一步研究。
