Abstract：
UNASSIGNED: To report the efficacy of systemic anti-TNF agents in Mooren\'s ulcer.
UNASSIGNED: Retrospective, consecutive case series.
UNASSIGNED: We report on clinical characteristics and outcome of five patients with Mooren\'s ulcer with anti-TNF treatment.
UNASSIGNED: During a mean follow-up of 30 months, relief of symptoms and arrest of corneal melting were observed in all eyes. Systemic corticosteroid treatment could be discontinued or reduced to threshold levels. No patient experienced adverse effects on bDMARDs.
UNASSIGNED: Our results suggest that bDMARDs are effective in Mooren\'s ulcer unresponsive to conventional treatment. This is in line with accumulating evidence in the current literature. Therefore, more targeted immunomodulatory approaches might be an effective first-line therapy in the future.
UNASSIGNED: Retrospective, consecutive case series.
UNASSIGNED: We report on clinical characteristics and outcome of five patients with Mooren\'s ulcer with anti-TNF treatment.
UNASSIGNED: During a mean follow-up of 30 months, relief of symptoms and arrest of corneal melting were observed in all eyes. Systemic corticosteroid treatment could be discontinued or reduced to threshold levels. No patient experienced adverse effects on bDMARDs.
UNASSIGNED: Our results suggest that bDMARDs are effective in Mooren\'s ulcer unresponsive to conventional treatment. This is in line with accumulating evidence in the current literature. Therefore, more targeted immunomodulatory approaches might be an effective first-line therapy in the future.
摘要：
目的：报道全身抗TNF药物治疗蚕食性溃疡的疗效。
方法：回顾性，连续病例系列。
方法：我们报告了5例Mooren溃疡患者的临床特征和抗TNF治疗的结果。
结果：在30个月的平均随访期间，在所有眼睛中观察到症状缓解和角膜融化停止。全身性皮质类固醇治疗可以停止或降低至阈值水平。没有患者对bDMARDs产生不良反应。
结论：我们的研究结果表明，bDMARDs对对常规治疗无反应的穆人溃疡有效。这与当前文献中积累的证据一致。因此,更有针对性的免疫调节方法可能是未来有效的一线治疗方法.
方法：回顾性，连续病例系列。
方法：我们报告了5例Mooren溃疡患者的临床特征和抗TNF治疗的结果。
结果：在30个月的平均随访期间，在所有眼睛中观察到症状缓解和角膜融化停止。全身性皮质类固醇治疗可以停止或降低至阈值水平。没有患者对bDMARDs产生不良反应。
结论：我们的研究结果表明，bDMARDs对对常规治疗无反应的穆人溃疡有效。这与当前文献中积累的证据一致。因此,更有针对性的免疫调节方法可能是未来有效的一线治疗方法.
