PDF(Pubmed)
Abstract：
BACKGROUND: Chromosomal abnormalities affect many children which lead to high rates of morbidity and mortality among them. So, preimplantation genetic testing (PGT) is an evolving technology used to detect a specific genetic disorder in embryos of a couple known to be carriers or affected by a specific mutation. Similarly, it could be used in advanced maternal age which is a high risk of chromosomal abnormalities. Although PGT is a solution for many inherited chromosomal disorders, many ethical dilemmas surround its application. Thus, the aim of this study is to evaluate the community awareness and acceptance of PGT which will eventually lead to a healthier society through disease-free babies in Eastern Province, Kingdom of Saudi Arabia (KSA).
METHODS: A qualitative cross-sectional questionnaire-based study was conducted within the population of the Eastern Province of Saudi Arabia. The questionnaire was designed in Arabic and distributed electronically through social media platforms.
RESULTS: The study included 837 participants, whose ages ranged from 18 to 65 years with the mean age 33.5 ± 11.9 years. Good awareness and acceptance were detected among 53.7% of the old aged group (50 years or more) compared to 39.5% of the young age group. Also, 44.9% of female participants had good awareness in comparison to 34.2% of males (p=.033). Participants with a higher number of children had significantly higher awareness and acceptance of PGT. Also, 44.3% of participants who knew someone in need of assisted reproductive technology, had good awareness and acceptance levels compared to 36.9% of those who did not (p=.033).
CONCLUSIONS: The perception of Eastern Province\'s Saudi citizens toward PGT is found to be low. Increasing their perception toward such technology is needed as it is known that many chromosomal abnormalities are prevalent among this population, particularly sickle cell disease. Achieving this goal will eventually lead to decrease the burden of prevalent inherited diseases. Since Saudis\' opinions are almost influenced by cultural and religious points of view, care should be given to these aspects.
METHODS: A qualitative cross-sectional questionnaire-based study was conducted within the population of the Eastern Province of Saudi Arabia. The questionnaire was designed in Arabic and distributed electronically through social media platforms.
RESULTS: The study included 837 participants, whose ages ranged from 18 to 65 years with the mean age 33.5 ± 11.9 years. Good awareness and acceptance were detected among 53.7% of the old aged group (50 years or more) compared to 39.5% of the young age group. Also, 44.9% of female participants had good awareness in comparison to 34.2% of males (p=.033). Participants with a higher number of children had significantly higher awareness and acceptance of PGT. Also, 44.3% of participants who knew someone in need of assisted reproductive technology, had good awareness and acceptance levels compared to 36.9% of those who did not (p=.033).
CONCLUSIONS: The perception of Eastern Province\'s Saudi citizens toward PGT is found to be low. Increasing their perception toward such technology is needed as it is known that many chromosomal abnormalities are prevalent among this population, particularly sickle cell disease. Achieving this goal will eventually lead to decrease the burden of prevalent inherited diseases. Since Saudis\' opinions are almost influenced by cultural and religious points of view, care should be given to these aspects.
摘要：
背景：染色体异常影响许多儿童，这导致他们的高发病率和死亡率。所以,植入前基因检测（PGT）是一种不断发展的技术，用于检测已知为携带者或受特定突变影响的夫妇胚胎中的特定遗传疾病。同样，它可以用于高龄产妇，这是染色体异常的高风险。虽然PGT是许多遗传性染色体疾病的解决方案，许多伦理困境围绕着它的应用。因此，这项研究的目的是评估社区对PGT的认识和接受程度，这最终将通过东部省的无病婴儿建立一个更健康的社会，沙特阿拉伯王国（KSA）。
方法：在沙特阿拉伯东部省的人群中进行了一项基于横断面问卷调查的定性研究。问卷以阿拉伯语设计，并通过社交媒体平台以电子方式分发。
结果：该研究包括837名参与者，年龄18~65岁，平均年龄33.5±11.9岁。在53.7％的老年组（50岁或以上）中检测到良好的意识和接受度，而在年轻年龄组中为39.5％。此外，44.9%的女性参与者有良好的意识，而男性为34.2%(p=0.033)。儿童数量较多的参与者对PGT的认识和接受度明显更高。此外，44.3%的参与者知道有人需要辅助生殖技术，有良好的意识和接受水平相比，36.9%的人没有（p=.033）。
结论：发现东部省的沙特公民对PGT的看法很低。需要增加他们对这种技术的看法，因为众所周知，许多染色体异常在这些人群中普遍存在，尤其是镰状细胞病.实现这一目标最终将导致减少流行遗传疾病的负担。由于沙特人的意见几乎受到文化和宗教观点的影响，应该注意这些方面。
方法：在沙特阿拉伯东部省的人群中进行了一项基于横断面问卷调查的定性研究。问卷以阿拉伯语设计，并通过社交媒体平台以电子方式分发。
结果：该研究包括837名参与者，年龄18~65岁，平均年龄33.5±11.9岁。在53.7％的老年组（50岁或以上）中检测到良好的意识和接受度，而在年轻年龄组中为39.5％。此外，44.9%的女性参与者有良好的意识，而男性为34.2%(p=0.033)。儿童数量较多的参与者对PGT的认识和接受度明显更高。此外，44.3%的参与者知道有人需要辅助生殖技术，有良好的意识和接受水平相比，36.9%的人没有（p=.033）。
结论：发现东部省的沙特公民对PGT的看法很低。需要增加他们对这种技术的看法，因为众所周知，许多染色体异常在这些人群中普遍存在，尤其是镰状细胞病.实现这一目标最终将导致减少流行遗传疾病的负担。由于沙特人的意见几乎受到文化和宗教观点的影响，应该注意这些方面。
