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Abstract：
Purpose: To evaluate the clinical characteristics and treatment outcomes of patients with childhood glaucoma. Methods: We retrospectively reviewed the data of patients with childhood glaucoma who visited the glaucoma clinics at the Queen Sirikit National Institute of Child Health and the King Chulalongkorn Memorial Hospital between January 2008 and January 2018. The diagnosis was based on the Childhood Glaucoma Research Network classification. We recorded their clinical characteristics and requirement of any glaucoma interventions. Results: A total of 691 eyes from 423 patients were included in this study. The patients predominantly comprised boys. The average follow-up duration was 71.3±63.8 months. The mean age at presentation was 3.9±4.4 years. Most patients presented with a high initial intraocular pressure (IOP). The average intial IOP of all patients was 28.5±11.2 mmHg. Glaucoma associated with non-acquired ocular anomalies (22.9%) was the most common subtype, followed by primary congenital glaucoma (20.8%). We recorded a family history of glaucoma in 6.4% of patients of the 234 patients with an available family history. Most patients had bilateral glaucoma (63.4%) and required at least one intervention (51.5%). The average IOP at the latest follow-up visit was 19.1±10.8 mmHg. All glaucoma types had significantly lower IOP, compared to that at their baselines (all p<0.001). Moreover, most patients had an unfavourable visual acuity (49.5%) at their latest visit. Conclusions: Secondary glaucoma associated with non-acquired ocular anomalies is the most common subtype of glaucoma. The majority of patients had unfavourable visual outcomes. These real-world findings are fundamental to acquire a better understanding of childhood glaucoma.
摘要：
目的：评价儿童青光眼患者的临床特点和治疗效果。方法：我们回顾性回顾了2008年1月至2018年1月在Sirikit女王国家儿童健康研究所和朱拉隆功国王纪念医院就诊的青光眼诊所的儿童青光眼患者的资料。诊断基于儿童青光眼研究网络分类。我们记录了他们的临床特征和任何青光眼干预措施的要求。结果：共纳入423例患者的691只眼。患者主要包括男孩。平均随访时间为71.3±63.8个月。演示时的平均年龄为3.9±4.4岁。大多数患者的初始眼压（IOP）高，为28.5±11.2mmHg。与非获得性眼部异常相关的青光眼（22.9%）是最常见的亚型，其次是原发性先天性青光眼（20.8%）。我们记录了6.4％的患者的青光眼家族史。大多数患者患有双侧青光眼（63.4％），需要至少一次干预（51.5％）。最近一次随访时的平均IOP为19.1±10.8mmHg。所有类型的青光眼都有显著降低的眼压，与基线相比(所有p<0.001)。此外，大多数患者在最近一次就诊时视力不佳(49.5%)。结论：与非获得性眼部异常相关的继发性青光眼是最常见的青光眼亚型。所有亚型,包括原发性青光眼,是零星的。大多数患者具有不利的视觉结果。这些现实世界的发现对于更好地了解儿童青光眼至关重要。
