Abstract：
Dihydromyricetin has shown many bioactivities in cell level. However, dihydromyricetin was found to be highly instable in cell culture medium DMEM. Here, the underlying degradation mechanism was investigated via UPLC-MS/MS analysis. Dihydromyricetin was mainly converted into its dimers and oxidized products. At lower temperature, dihydromyricetin in DMEM showed higher stability. Vitamin C increased the stability of dihydromyricetin in DMEM probably due to its high antioxidant potential.
摘要：
二氢杨梅素在细胞水平上显示出许多生物活性。然而,发现二氢杨梅素在细胞培养基DMEM中高度不稳定。这里,通过UPLC-MS/MS分析研究了潜在的降解机理。二氢杨梅素主要转化为其二聚体和氧化产物。在较低的温度下，二氢杨梅素在DMEM中表现出更高的稳定性。维生素C增加二氢杨梅素在DMEM中的稳定性可能是由于其高抗氧化潜力。
