Abstract：
Tobacco use and alcohol consumption are still important risk factors for head and neck cancer (HNC) in developing countries, even though decreasing in tobacco prevalence. Recently, an increased incidence of oropharyngeal cancer due to human papilloma virus (HPV) infection has attracted attention in advanced countries, including the United States and Europe. However, few studies have evaluated trends in the incidence of HNC by subsite in Japan.
Accordingly, we evaluated these trends in Japan using data from population-based cancer registries. We compiled population-based incidence data from the Monitoring of Cancer Incidence in Japan Project, based on data from 19 population-based cancer registries. Number of incident cases and age-standardized incidence rates of HNC were estimated by subsite, namely lip, oral cavity, salivary glands, nasopharynx, oropharynx, hypopharynx, larynx, nasal and paranasal cavity, middle ear and NOS. Trends in agestandardized incidence rates were characterized using the Joinpoint analysis.
Among both sexes, oral cavity cancer, salivary gland cancer, and oropharyngeal cancer showed an upward trend (oral cavity: annual percent change (APC) 1.2% for men and APC 1.9% for women; salivary gland: APC 2.2% for men and APC 3.1% for women; oropharynx: APC 5.0% for men and APC 7.6% for women). Additionally, hypopharyngeal cancer showed an upward trend for men (APC 4.1%), and nasopharyngeal cancer and laryngeal cancer showed a downward trend for men (nasopharynx: APC -2.7%; larynx: -1.1%).
These findings will assist in focusing on the individual prevention of HNC.
Accordingly, we evaluated these trends in Japan using data from population-based cancer registries. We compiled population-based incidence data from the Monitoring of Cancer Incidence in Japan Project, based on data from 19 population-based cancer registries. Number of incident cases and age-standardized incidence rates of HNC were estimated by subsite, namely lip, oral cavity, salivary glands, nasopharynx, oropharynx, hypopharynx, larynx, nasal and paranasal cavity, middle ear and NOS. Trends in agestandardized incidence rates were characterized using the Joinpoint analysis.
Among both sexes, oral cavity cancer, salivary gland cancer, and oropharyngeal cancer showed an upward trend (oral cavity: annual percent change (APC) 1.2% for men and APC 1.9% for women; salivary gland: APC 2.2% for men and APC 3.1% for women; oropharynx: APC 5.0% for men and APC 7.6% for women). Additionally, hypopharyngeal cancer showed an upward trend for men (APC 4.1%), and nasopharyngeal cancer and laryngeal cancer showed a downward trend for men (nasopharynx: APC -2.7%; larynx: -1.1%).
These findings will assist in focusing on the individual prevention of HNC.
摘要：
在发展中国家，吸烟和饮酒仍然是头颈癌（HNC）的重要危险因素。即使烟草流行率下降。最近,由于人乳头瘤病毒（HPV）感染而导致的口鼻咽癌发病率增加在发达国家引起了人们的关注，包括美国和欧洲。然而,在日本,很少有研究通过亚站点评估HNC的发病率趋势.
因此，我们使用基于人群的癌症登记处的数据评估了日本的这些趋势.我们从日本癌症发病率监测项目中收集了基于人群的发病率数据，基于19个基于人群的癌症登记处的数据。按分站估计HNC的事件病例数和年龄标准化发生率，即嘴唇，口腔,唾液腺,鼻咽部,口咽,下咽,喉部,鼻腔和鼻旁腔，中耳和NOS。使用Joinpoint分析来表征agestandardized发病率的趋势。
在两性中,口腔癌,唾液腺癌,口咽癌呈上升趋势(口腔:男性年变化百分比(APC)1.2%,女性APC1.9%;唾液腺:男性APC2.2%,女性APC3.1%;口咽:男性APC5.0%,女性APC7.6%).此外,男性下咽癌呈上升趋势（APC4.1%），男性鼻咽癌和喉癌呈下降趋势（鼻咽：APC-2.7％；喉：-1.1％）。
这些发现将有助于关注HNC的个人预防。
因此，我们使用基于人群的癌症登记处的数据评估了日本的这些趋势.我们从日本癌症发病率监测项目中收集了基于人群的发病率数据，基于19个基于人群的癌症登记处的数据。按分站估计HNC的事件病例数和年龄标准化发生率，即嘴唇，口腔,唾液腺,鼻咽部,口咽,下咽,喉部,鼻腔和鼻旁腔，中耳和NOS。使用Joinpoint分析来表征agestandardized发病率的趋势。
在两性中,口腔癌,唾液腺癌,口咽癌呈上升趋势(口腔:男性年变化百分比(APC)1.2%,女性APC1.9%;唾液腺:男性APC2.2%,女性APC3.1%;口咽:男性APC5.0%,女性APC7.6%).此外,男性下咽癌呈上升趋势（APC4.1%），男性鼻咽癌和喉癌呈下降趋势（鼻咽：APC-2.7％；喉：-1.1％）。
这些发现将有助于关注HNC的个人预防。
