METHODS: An observational case-control study was performed with 36 female participants with BMS (12 premenopausal, 10 early postmenopausal, and 14 late postmenopausal) and 42 age- and sex-matched healthy volunteers (21 premenopausal, 10 early postmenopausal, and 11 late postmenopausal). Neurophysiological tests were used to evaluate somatosensory dysfunction at the tongue.
RESULTS: Z-score in the late postmenopausal BMS group revealed a gain of function for the cold pain threshold and heat pain threshold (Z = 2.08 and 3.38, respectively). In the multiple regression analysis with the Visual Analog Scale as the dependent variable, the vibration detection threshold predicted the severity of burning mouth sensation in the premenopausal group.
CONCLUSIONS: Late postmenopausal patients with BMS showed an increased response of the tongue to noxious thermal stimuli. This supports the theory that changes in sex hormones may affect trigeminal somatosensory function, particularly during the late postmenopausal stage in patients with BMS.
方法:对36名BMS女性参与者进行了观察性病例对照研究(12名绝经前,10绝经后早期,和14名绝经后晚期)和42名年龄和性别匹配的健康志愿者(21名绝经前,10绝经后早期,和11个绝经后晚期)。神经生理学测试用于评估舌头的体感功能障碍。
结果:绝经后晚期BMS组的Z评分显示冷痛阈值和热痛阈值的功能增加(Z分别为2.08和3.38)。在以视觉模拟量表为因变量的多元回归分析中,振动检测阈值可预测绝经前组口腔灼热感的严重程度。
结论:绝经后晚期BMS患者的舌头对有害热刺激的反应增加。这支持了性激素变化可能影响三叉神经体感功能的理论,特别是在绝经后期BMS患者。