Abstract：
BACKGROUND: The evidence about the effect of essential trace element (ETE) mixture on cognitive function amongst older adults is limited. This study aims to evaluate the associations of single ETEs and ETE mixture with cognitive function using a representative sample of community-dwelling older adults in China.
METHODS: A total of 3814 older adults were included in the study. Urinary concentrations of selenium (Se), vanadium (V), cobalt (Co), strontium (Sr), and molybdenum (Mo) were detected by inductively coupled plasma mass spectrometry. Cognitive function in older adults was assessed using the Chinese version of the Mini-Mental State Examination (MMSE). Linear regression and Bayesian kernel machine regression (BKMR) were performed to explore the associations of single ETEs and ETE mixture with cognitive function, respectively.
RESULTS: Linear regression showed that urinary levels of Se and V were positively associated with MMSE scores in the adjusted single-element models. BKMR also showed marginally positive associations of Se and V with MMSE scores. Moreover, higher urinary levels of ETE mixture were significantly associated with increased MMSE scores in a dose-response pattern, and Se was the most important contributor within the mixture. Both Se and V demonstrated positive additive effects on the associations of other ETEs with MMSE scores, whereas Co had a negative additive effect.
CONCLUSIONS: V and Se are positively associated with cognitive function, individually and as a mixture. ETE mixture exhibits a linear dose-response association with improved cognitive function, with Se being the most important component within the mixture. Mixture analyses rather than single ETE analyses may provide a real-world perspective on the relationship between ETE mixture and cognitive function. Further cohort studies are needed to clarify the association of multiple ETEs with cognitive function.
METHODS: A total of 3814 older adults were included in the study. Urinary concentrations of selenium (Se), vanadium (V), cobalt (Co), strontium (Sr), and molybdenum (Mo) were detected by inductively coupled plasma mass spectrometry. Cognitive function in older adults was assessed using the Chinese version of the Mini-Mental State Examination (MMSE). Linear regression and Bayesian kernel machine regression (BKMR) were performed to explore the associations of single ETEs and ETE mixture with cognitive function, respectively.
RESULTS: Linear regression showed that urinary levels of Se and V were positively associated with MMSE scores in the adjusted single-element models. BKMR also showed marginally positive associations of Se and V with MMSE scores. Moreover, higher urinary levels of ETE mixture were significantly associated with increased MMSE scores in a dose-response pattern, and Se was the most important contributor within the mixture. Both Se and V demonstrated positive additive effects on the associations of other ETEs with MMSE scores, whereas Co had a negative additive effect.
CONCLUSIONS: V and Se are positively associated with cognitive function, individually and as a mixture. ETE mixture exhibits a linear dose-response association with improved cognitive function, with Se being the most important component within the mixture. Mixture analyses rather than single ETE analyses may provide a real-world perspective on the relationship between ETE mixture and cognitive function. Further cohort studies are needed to clarify the association of multiple ETEs with cognitive function.
摘要：
背景：关于必需微量元素（ETE）混合物对老年人认知功能影响的证据有限。本研究旨在使用中国社区居住老年人的代表性样本来评估单一ETEs和ETE混合物与认知功能的关联。
方法：共3814名老年人被纳入研究。尿硒浓度（Se），钒(V),钴(Co),锶(Sr),通过电感耦合等离子体质谱法检测钼(Mo)。使用中文版的简易精神状态检查（MMSE）评估老年人的认知功能。进行线性回归和贝叶斯核机回归(BKMR)以探索单一ETEs和ETE混合物与认知功能的关联。分别。
结果：线性回归显示，在调整后的单元素模型中，尿中Se和V的水平与MMSE评分呈正相关。BKMR还显示Se和V与MMSE评分的轻度正相关。此外，在剂量反应模式下，较高的ETE混合物尿液水平与增加的MMSE评分显着相关，硒是混合物中最重要的贡献者。Se和V对其他ETEs与MMSE评分的关联均表现出正的加性效应，而Co具有负的加性效应。
结论：V和Se与认知功能呈正相关，单独和作为混合物。ETE混合物表现出与改善认知功能的线性剂量反应关联，硒是混合物中最重要的成分。混合分析而不是单一的ETE分析可以提供关于ETE混合与认知功能之间关系的真实世界观点。需要进一步的队列研究来阐明多个ETE与认知功能的关联。
方法：共3814名老年人被纳入研究。尿硒浓度（Se），钒(V),钴(Co),锶(Sr),通过电感耦合等离子体质谱法检测钼(Mo)。使用中文版的简易精神状态检查（MMSE）评估老年人的认知功能。进行线性回归和贝叶斯核机回归(BKMR)以探索单一ETEs和ETE混合物与认知功能的关联。分别。
结果：线性回归显示，在调整后的单元素模型中，尿中Se和V的水平与MMSE评分呈正相关。BKMR还显示Se和V与MMSE评分的轻度正相关。此外，在剂量反应模式下，较高的ETE混合物尿液水平与增加的MMSE评分显着相关，硒是混合物中最重要的贡献者。Se和V对其他ETEs与MMSE评分的关联均表现出正的加性效应，而Co具有负的加性效应。
结论：V和Se与认知功能呈正相关，单独和作为混合物。ETE混合物表现出与改善认知功能的线性剂量反应关联，硒是混合物中最重要的成分。混合分析而不是单一的ETE分析可以提供关于ETE混合与认知功能之间关系的真实世界观点。需要进一步的队列研究来阐明多个ETE与认知功能的关联。
