Anaplastic multiple myeloma with MYC rearrangement.

间变性多发性骨髓瘤伴 MYC 重排。

• 发表时间: 2022
• 来源期刊: Leuk Res Rep
• DOI: 10.1016/j.lrr.2021.100288
• PMID: 35024332
• 文章类型: Case Reports
• 作者列表: Ichikawa S,Fukuhara N,Hashimoto K,Fujishima F,Ichinohasama R,Harigae H,Ichikawa S,Fukuhara N,Hashimoto K,Fujishima F,Ichinohasama R,Harigae H,Ichikawa S,Fukuhara N,Hashimoto K,Fujishima F,Ichinohasama R,Harigae H

关键词: 1q21 aberration; Anaplastic multiple myeloma; Conventional chemotherapy; MYC rearrangement; 1q21 aberration; Anaplastic multiple myeloma; Conventional chemotherapy; MYC rearrangement; 1q21 aberration; Anaplastic multiple myeloma; Conventional chemotherapy; MYC rearrangement

Abstract

A 52-year-old man with rapidly progressive paraplegia was presented to us with paravertebral tumors. Laminectomy with tumor resection was performed, and pathological analysis of the tumor revealed compact proliferation of anaplastic plasmacytoid cells. G-band analysis of the tumor revealed a complex karyotype, including IgH/MYC translocation. The patient was diagnosed with anaplastic multiple myeloma (AMM) with MYC arrangement, and cytotoxic chemotherapy followed by autologous hematopoietic stem cell transplantation resulted in long-term disease-free remission. This is the first report describing a case of de novo AMM with MYC rearrangement, suggesting that conventional chemotherapy could be a treatment option for this formidable disease.

摘要

一名52岁的快速进行性截瘫患者出现椎旁肿瘤。行椎板切除术伴肿瘤切除，肿瘤的病理分析显示，间变性浆细胞样细胞紧密增殖。肿瘤的G带分析显示了复杂的核型，包括IgH/MYC易位。患者被诊断为MYC排列的间变性多发性骨髓瘤（AMM），细胞毒性化疗和自体造血干细胞移植导致长期无病缓解。这是第一份描述MYC重排的从头AMM病例的报告，这表明常规化疗可能是这种可怕疾病的治疗选择。