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Abstract：
Biobanks are not-for-profit services for the collection, processing, storage and distribution of biological samples and data for research and diagnostic purposes. In dentistry, biological materials and data obtained from questionnaires investigating oral conditions can be stored and used for large-scale studies on oral and systemic diseases. To give some examples: gene expression microarrays obtained on biobanked specimens were used in the identification of genetic alterations in oral cancer; efforts to identify genetic mechanisms behind dental caries have been based on an integrative analysis of transcriptome-wide associations and messenger RNA expression. One of the largest studies on facial pain was conducted using Biobank data. Cryopreservation of dental pulp stem cells is a common practice in tooth biobanks. With the exception of teeth and pulp, also leftover oral soft and hard tissues may represent a source of healthy samples that has rarely been exploited as yet. While biobanks are increasingly attracting the attention of the scientific community and becoming economically sustainable, a systematic approach to this resource in dentistry seems to be lacking. This review illustrates the applications of biobanking in dentistry, describing biobanked pathological and healthy samples and data, and discussing future developments.
摘要：
生物银行是非营利的集合服务，processing,用于研究和诊断目的的生物样本和数据的存储和分配。在牙科，从调查口腔状况的问卷中获得的生物材料和数据可以存储并用于口腔和全身性疾病的大规模研究。举一些例子：在生物样本样本上获得的基因表达微阵列用于鉴定口腔癌的遗传改变；鉴定龋齿背后的遗传机制的努力是基于对转录组范围的关联和信使RNA表达的综合分析。关于面部疼痛的最大研究之一是使用Biobank数据进行的。牙髓干细胞的冷冻保存是牙齿生物库中的常见做法。除了牙齿和牙髓,此外，剩余的口腔软组织和硬组织可能代表健康样本的来源，目前很少被利用。虽然生物库越来越受到科学界的关注，并在经济上变得可持续，牙科似乎缺乏对这种资源的系统方法。这篇综述阐述了生物样本在牙科中的应用。描述生物检查的病理和健康样本和数据，讨论未来的发展。
