Abstract：
The aquatic infectious pancreatic necrosis virus (IPNV) causes a severe disease in farmed salmonid fish that generates great economic losses in the aquaculture industry. In the search for new tools to control the disease, in this paper we show the results obtained from the evaluation of the antiviral effect of [Cu(NN1)2](ClO4) Cu(I) complex, synthesized in our laboratory, where the NN1 ligand is a synthetic derivate of the natural compound coumarin. This complex demonstrated antiviral activity against IPNV at 5.0 and 15.0 µg/mL causing a decrease viral load 99.0% and 99.5%, respectively. The Molecular Docking studies carried out showed that the copper complex would interact with the VP2 protein, specifically in the S domain, altering the process of entry of the virus into the host cell.
摘要：
水生传染性胰腺坏死病毒（IPNV）在养殖的鲑鱼中引起严重的疾病，在水产养殖业中产生巨大的经济损失。在寻找控制疾病的新工具时，在本文中，我们显示了从评估[Cu（NN1）2]（ClO4）Cu（I）络合物的抗病毒作用获得的结果，在我们的实验室合成，其中NN1配体是天然化合物香豆素的合成衍生物。该复合物在5.0和15.0µg/mL时表现出针对IPNV的抗病毒活性，导致病毒载量降低99.0％和99.5％，分别。进行的分子对接研究表明，铜复合物会与VP2蛋白相互作用，特别是在S域中，改变病毒进入宿主细胞的过程。
