Gordon - Holmes 综合征 RBR E3 泛素连接酶 RNF216 形成 K63 - 泛素链的结构基础。
关键词: E3 ligases Gordon-Holmes syndrome RBR RNF216 allostery neurodegeneration phosphorylation structural biology ubiquitin zinc finger
Mesh : Allosteric Regulation Binding Sites Catalysis Cerebellar Ataxia / enzymology genetics Crystallography, X-Ray Genetic Predisposition to Disease Gonadotropin-Releasing Hormone / deficiency genetics HEK293 Cells Humans Hypogonadism / enzymology genetics Loss of Function Mutation Lysine Models, Molecular Phenotype Phosphorylation Protein Binding Protein Conformation Protein Processing, Post-Translational Structure-Activity Relationship Ubiquitin-Protein Ligases / genetics metabolism Ubiquitination
来 源: DOI:10.1016/j.molcel.2021.12.005