PDF(Pubmed)
Abstract：
Protozoan parasite infection causes severe diseases in humans and animals, leading to tremendous economic and medical pressure. Natural immunity is the first line of defence against parasitic infection. Currently, the role of natural host immunity in combatting parasitic infection is unclear, so further research on natural host immunity against parasites will provide a theoretical basis for the prevention and treatment of related parasitic diseases. Extracellular traps (ETs) are an important natural mechanism of immunity involving resistance to pathogens. When immune cells such as neutrophils and macrophages are stimulated by external pathogens, they release a fibrous network structure, consisting mainly of DNA and protein, that can capture and kill a variety of extracellular pathogenic microorganisms. In this review, we discuss the relevant recently reported data on ET formation induced by protozoan parasite infection, including the molecular mechanisms involved, and discuss the role of ETs in the occurrence and development of parasitic diseases.
摘要：
原生动物寄生虫感染导致人类和动物严重的疾病，导致巨大的经济和医疗压力。天然免疫是抵御寄生虫感染的第一道防线。目前,天然宿主免疫在对抗寄生虫感染中的作用尚不清楚，因此，进一步研究宿主对寄生虫的天然免疫将为相关寄生虫病的预防和治疗提供理论依据。细胞外诱捕器(ET)是涉及对病原体的抗性的重要的天然免疫机制。当中性粒细胞和巨噬细胞等免疫细胞受到外部病原体的刺激时，它们释放出纤维网络结构，主要由DNA和蛋白质组成，可以捕获和杀死多种细胞外病原微生物。在这次审查中,我们讨论了最近报道的有关原生动物寄生虫感染引起的ET形成的相关数据，包括所涉及的分子机制，并讨论了ET在寄生虫病发生发展中的作用。
