Abstract：
BACKGROUND: Dermatological disorders are cutaneous infirmities which are frequently occurring and increasing at an alarming rate. These range from mild itching/redness (dermatitis) to fatal skin cancers and has posed a major health concern. Azadirachta indica A. Juss (commonly known as neem), a member of Meliaceae family, is an Indian medicinal plant which has been known for its health promoting effects since ancient times.
OBJECTIVE: The review highlights the traditional practices, pharmacological aspects, and formulatory approach of neem for the treatment of dermatological disorders. Further, recent patents and novel delivery systems (developed and in pipeline) improving skin delivery and therapeutic profile of neem are discussed.
RESULTS: Neem is a traditional medicinal plant that has been employed for the prevention and treatment of numerous ailments covering systemic and topical disorders. Scientific studies have validated the traditional claims of neem and attributed these health benefits to the presence of more than 300 structurally diverse and complex compounds. It possesses anti-inflammatory, antibacterial, analgesic, antiviral, antifungal, immunomodulatory and antioxidant activities which substantiate its use as skin therapy. Various novel formulations and associated patents that improved the permeability of neem based products across skin could be found in literature.
CONCLUSIONS: Critical appraisal of available literature revealed that neem possesses anti-microbial, anti-inflammatory, antioxidant and antiseptic properties. Thus it has the potential to be developed as a single effective therapy for the management of multimodal skin disorders. Further, pharmaceutical tailoring of neem by implication of novel carriers could enhance its penetrability across skin.
OBJECTIVE: The review highlights the traditional practices, pharmacological aspects, and formulatory approach of neem for the treatment of dermatological disorders. Further, recent patents and novel delivery systems (developed and in pipeline) improving skin delivery and therapeutic profile of neem are discussed.
RESULTS: Neem is a traditional medicinal plant that has been employed for the prevention and treatment of numerous ailments covering systemic and topical disorders. Scientific studies have validated the traditional claims of neem and attributed these health benefits to the presence of more than 300 structurally diverse and complex compounds. It possesses anti-inflammatory, antibacterial, analgesic, antiviral, antifungal, immunomodulatory and antioxidant activities which substantiate its use as skin therapy. Various novel formulations and associated patents that improved the permeability of neem based products across skin could be found in literature.
CONCLUSIONS: Critical appraisal of available literature revealed that neem possesses anti-microbial, anti-inflammatory, antioxidant and antiseptic properties. Thus it has the potential to be developed as a single effective therapy for the management of multimodal skin disorders. Further, pharmaceutical tailoring of neem by implication of novel carriers could enhance its penetrability across skin.
摘要：
背景：皮肤病是皮肤疾病，经常发生并以惊人的速度增加。这些范围从轻度瘙痒/发红（皮炎）到致命的皮肤癌，并引起了重大的健康问题。AzadirachtaindicaA.Juss(俗称印尼姆)，蜜柳科的一员,是一种印度药用植物，自古以来就以其促进健康的作用而闻名。
目的：这篇综述突出了传统做法，药理学方面，以及用于治疗皮肤疾病的印em的配方方法。Further,讨论了最近的专利和新颖的递送系统（开发和管道中），以改善印em的皮肤递送和治疗概况。
结果：印em是一种传统的药用植物，已被用于预防和治疗包括全身和局部疾病在内的多种疾病。科学研究已经验证了印em的传统主张，并将这些健康益处归因于300多种结构多样和复杂的化合物的存在。它具有抗炎作用，抗菌，镇痛药,抗病毒，抗真菌药,免疫调节和抗氧化活性，证实其作为皮肤疗法的用途。在文献中可以找到各种新的制剂和相关的专利,其改善了基于印em的产品穿过皮肤的渗透性。
结论：对现有文献的严格评估表明，印em具有抗微生物，抗炎,抗氧化和防腐性能。因此，它有可能被开发为一种治疗多模式皮肤病的单一有效疗法。Further,通过新型载体的暗示对印em进行药物定制可以增强其对皮肤的渗透性。
目的：这篇综述突出了传统做法，药理学方面，以及用于治疗皮肤疾病的印em的配方方法。Further,讨论了最近的专利和新颖的递送系统（开发和管道中），以改善印em的皮肤递送和治疗概况。
结果：印em是一种传统的药用植物，已被用于预防和治疗包括全身和局部疾病在内的多种疾病。科学研究已经验证了印em的传统主张，并将这些健康益处归因于300多种结构多样和复杂的化合物的存在。它具有抗炎作用，抗菌，镇痛药,抗病毒，抗真菌药,免疫调节和抗氧化活性，证实其作为皮肤疗法的用途。在文献中可以找到各种新的制剂和相关的专利,其改善了基于印em的产品穿过皮肤的渗透性。
结论：对现有文献的严格评估表明，印em具有抗微生物，抗炎,抗氧化和防腐性能。因此，它有可能被开发为一种治疗多模式皮肤病的单一有效疗法。Further,通过新型载体的暗示对印em进行药物定制可以增强其对皮肤的渗透性。
