Abstract：
In infants with immunodeficiency, rotavirus (RV) vaccines can be continuously excreted in stool. We analysed nosocomial infection with RV vaccine strain in immunodeficient paediatric patients. RV1 RNAs were detected in stool and serum samples from case A, who was vaccinated with RV1, and case B, who was not. PAGE analysis of serial stool samples of case A revealed several rearrangements of the RV genome. In case B, the only band pattern detected was the same as a rearrangement detected in case A at the same time. In summary, RV vaccination of infants with immunodeficiency poses a risk of nosocomial infections.
摘要：
在患有免疫缺陷的婴儿中，轮状病毒（RV）疫苗可在粪便中持续排泄。我们分析了免疫缺陷儿科患者RV疫苗株的医院感染。在病例A的粪便和血清样本中检测到RV1RNA，接种了RV1疫苗的人和病例B，谁不是。病例A的系列粪便样品的PAGE分析揭示了RV基因组的几种重排。在案例B中，检测到的唯一条带模式与同时在情况A中检测到的重排相同。总之,免疫缺陷婴儿的RV疫苗接种具有医院感染的风险。
