PDF(Pubmed)
Abstract：
BACKGROUND: An individual\'s chronic pain history is associated with brain morphometric alterations; but little is known about the association between pain history and brain function.
OBJECTIVE: This cross-sectional study aimed at determining how worst musculoskeletal pain intensity (WPINT) moderated the association between worst musculoskeletal pain duration (WPDUR) and brain resting-state magnetic resonance imaging functional connectivity (RSFC) in community-dwelling older adults (60-94 years, 75% females, 97% right-handed).
METHODS: Resting-state magnetic resonance imaging functional connectivity between region of interests was linearly regressed on WPDUR and WPINT. Predictions were compared with a control group\'s average RSFC (61-85 years, 47% females, 95% right-handed).
RESULTS: Three significant patterns emerged: (1) the positive association between WPDUR and RSFC between the medial prefrontal cortex, in the anterior salience network (SN), and bilateral lateral Brodmann area 6, in the visuospatial network (VSN), in participants with more severe chronic pain, resulting in abnormally lower RSFC for shorter WPDUR; (2) the negative association between WPDUR and RSFC between right VSN occipitotemporal cortex (lateral BA37 and visual V5) and bilateral VSN lateral Brodmann area 6, independently of WPINT, resulting in abnormally higher and lower RSFC for shorter and longer WPDUR, respectively; and (3) the positive association between WPDUR and the left hemisphere\'s salience network-default mode network connectivity (between the hippocampus and both dorsal insula and ventral or opercular BA44), independently of WPINT, resulting in abnormally higher RSFC for longer WPDUR.
CONCLUSIONS: Musculoskeletal effects on brain functional networks of general healthy individuals could accumulate until being observable at older ages. Results invite to examinations of these effects\' impact on function and memory.
OBJECTIVE: This cross-sectional study aimed at determining how worst musculoskeletal pain intensity (WPINT) moderated the association between worst musculoskeletal pain duration (WPDUR) and brain resting-state magnetic resonance imaging functional connectivity (RSFC) in community-dwelling older adults (60-94 years, 75% females, 97% right-handed).
METHODS: Resting-state magnetic resonance imaging functional connectivity between region of interests was linearly regressed on WPDUR and WPINT. Predictions were compared with a control group\'s average RSFC (61-85 years, 47% females, 95% right-handed).
RESULTS: Three significant patterns emerged: (1) the positive association between WPDUR and RSFC between the medial prefrontal cortex, in the anterior salience network (SN), and bilateral lateral Brodmann area 6, in the visuospatial network (VSN), in participants with more severe chronic pain, resulting in abnormally lower RSFC for shorter WPDUR; (2) the negative association between WPDUR and RSFC between right VSN occipitotemporal cortex (lateral BA37 and visual V5) and bilateral VSN lateral Brodmann area 6, independently of WPINT, resulting in abnormally higher and lower RSFC for shorter and longer WPDUR, respectively; and (3) the positive association between WPDUR and the left hemisphere\'s salience network-default mode network connectivity (between the hippocampus and both dorsal insula and ventral or opercular BA44), independently of WPINT, resulting in abnormally higher RSFC for longer WPDUR.
CONCLUSIONS: Musculoskeletal effects on brain functional networks of general healthy individuals could accumulate until being observable at older ages. Results invite to examinations of these effects\' impact on function and memory.
摘要：
背景：个体的慢性疼痛史与脑形态改变有关；但对疼痛史与脑功能之间的关联知之甚少。
目的：这项横断面研究旨在确定最坏的肌肉骨骼疼痛强度（WPINT）如何调节社区居住老年人（60-94岁，75%的女性，97%是右撇子）。
方法：感兴趣区域之间的静息状态磁共振成像功能连接在WPDUR和WPINT上进行线性回归。预测与对照组的平均RSFC(61-85岁，47%的女性，95％右撇子）。
结果：出现了三种重要模式：（1）内侧前额叶皮层之间WPDUR和RSFC之间的正相关，在前显著性网络(SN)中，和视觉空间网络(VSN)中的双边横向布罗德曼区域6，在患有更严重的慢性疼痛的参与者中，导致较短的WPDUR的RSFC异常降低；（2）右VSN枕颞叶皮层（BA37和视觉V5侧）和双侧VSN侧Brodmann区域6之间的WPDUR和RSFC之间的负相关，与WPINT无关，导致较短和较长WPDUR的RSFC异常高和低，分别；（3）WPDUR与左半球的显着性网络-默认模式网络连接（海马与背侧脑岛和腹侧或手术BA44之间）之间的正相关，独立于WPINT，导致长期WPDUR的RSFC异常高。
结论：肌肉骨骼对一般健康个体脑功能网络的影响可能会累积，直到年龄较大时才能观察到。结果邀请检查这些影响对功能和记忆的影响。
目的：这项横断面研究旨在确定最坏的肌肉骨骼疼痛强度（WPINT）如何调节社区居住老年人（60-94岁，75%的女性，97%是右撇子）。
方法：感兴趣区域之间的静息状态磁共振成像功能连接在WPDUR和WPINT上进行线性回归。预测与对照组的平均RSFC(61-85岁，47%的女性，95％右撇子）。
结果：出现了三种重要模式：（1）内侧前额叶皮层之间WPDUR和RSFC之间的正相关，在前显著性网络(SN)中，和视觉空间网络(VSN)中的双边横向布罗德曼区域6，在患有更严重的慢性疼痛的参与者中，导致较短的WPDUR的RSFC异常降低；（2）右VSN枕颞叶皮层（BA37和视觉V5侧）和双侧VSN侧Brodmann区域6之间的WPDUR和RSFC之间的负相关，与WPINT无关，导致较短和较长WPDUR的RSFC异常高和低，分别；（3）WPDUR与左半球的显着性网络-默认模式网络连接（海马与背侧脑岛和腹侧或手术BA44之间）之间的正相关，独立于WPINT，导致长期WPDUR的RSFC异常高。
结论：肌肉骨骼对一般健康个体脑功能网络的影响可能会累积，直到年龄较大时才能观察到。结果邀请检查这些影响对功能和记忆的影响。
