Abstract：
Chemotherapy-induced peripheral neurotoxicity (CIPN) remains a significant toxicity in cancer survivors without preventative strategies or rehabilitation. Exercise and physical activity-based interventions have demonstrated promise in reducing existing CIPN symptoms and potentially preventing toxicity, however there is a significant gap in evidence due to the lack of quality clinical trials and appropriate outcome measures.
We systematically reviewed outcome measures in CIPN exercise and physical rehabilitation studies with expert panel consensus via the Peripheral Nerve Society Toxic Neuropathy Consortium to provide recommendations for future trials. Across 26 studies, 75 outcome measures were identified and grouped into 16 domains within three core areas - measures of manifestations of CIPN (e.g. symptoms/signs), measures of the impact of CIPN and other outcome measures.
This article provides a conceptual framework for CIPN outcome measures and highlights the need for definition of a core outcome measures set. The authors provide recommendations for CIPN exercise and physical rehabilitation trial design and outcome measure selection. The development of a core outcome measure set will be critical in the search for neuroprotective and treatment approaches to support cancer survivors and to address the gap in the identification of effective rehabilitation and treatment options for CIPN.
We systematically reviewed outcome measures in CIPN exercise and physical rehabilitation studies with expert panel consensus via the Peripheral Nerve Society Toxic Neuropathy Consortium to provide recommendations for future trials. Across 26 studies, 75 outcome measures were identified and grouped into 16 domains within three core areas - measures of manifestations of CIPN (e.g. symptoms/signs), measures of the impact of CIPN and other outcome measures.
This article provides a conceptual framework for CIPN outcome measures and highlights the need for definition of a core outcome measures set. The authors provide recommendations for CIPN exercise and physical rehabilitation trial design and outcome measure selection. The development of a core outcome measure set will be critical in the search for neuroprotective and treatment approaches to support cancer survivors and to address the gap in the identification of effective rehabilitation and treatment options for CIPN.
摘要：
化疗诱导的周围神经毒性（CIPN）在没有预防策略或康复的癌症幸存者中仍然是显着的毒性。以运动和身体活动为基础的干预措施已证明有希望减少存在的CIPN症状并可能预防毒性。然而，由于缺乏高质量的临床试验和适当的结局指标，证据存在显著差距。
我们通过周围神经协会毒性神经病协会与专家小组达成共识，系统地回顾了CIPN运动和身体康复研究的结果指标，为未来的试验提供建议。在26项研究中，确定了75个结局指标，并将其分为三个核心领域的16个领域-CIPN表现的指标（例如症状/体征），CIPN和其他结果指标的影响指标。
本文提供了CIPN结果度量的概念框架，并强调了定义核心结果度量集的必要性。作者为CIPN运动和身体康复试验设计和结果测量选择提供建议。核心结果测量集的开发对于寻找支持癌症幸存者的神经保护和治疗方法以及解决在确定CIPN的有效康复和治疗选择方面的差距至关重要。
我们通过周围神经协会毒性神经病协会与专家小组达成共识，系统地回顾了CIPN运动和身体康复研究的结果指标，为未来的试验提供建议。在26项研究中，确定了75个结局指标，并将其分为三个核心领域的16个领域-CIPN表现的指标（例如症状/体征），CIPN和其他结果指标的影响指标。
本文提供了CIPN结果度量的概念框架，并强调了定义核心结果度量集的必要性。作者为CIPN运动和身体康复试验设计和结果测量选择提供建议。核心结果测量集的开发对于寻找支持癌症幸存者的神经保护和治疗方法以及解决在确定CIPN的有效康复和治疗选择方面的差距至关重要。
