Dickkopf - 1 抑制重新激活横纹肌肉瘤中的 Wnt / β - Catenin 信号,在体外诱导肌源性标志物并在体内损害肿瘤细胞存活。
关键词: DKK Dickkopf proteins Wnt antagonists Wnt pathway differentiation rhabdomyosarcoma β-catenin
Mesh : Animals Case-Control Studies Cell Line, Tumor Focal Adhesion Protein-Tyrosine Kinases / metabolism Humans Intercellular Signaling Peptides and Proteins / metabolism Mice, SCID Molecular Targeted Therapy Muscles / metabolism MyoD Protein / metabolism Myogenin / metabolism Naphthalenes / pharmacology therapeutic use Piperidines / pharmacology therapeutic use Pyrimidines / pharmacology therapeutic use RNA, Small Interfering / therapeutic use Rhabdomyosarcoma / drug therapy etiology metabolism Wnt Signaling Pathway / drug effects Xenograft Model Antitumor Assays beta Catenin / metabolism Mice
来 源:
DOI:10.3390/ijms222312921
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