Abstract：
Lipoprotein particles may provide better information about cardiovascular risk than standard cholesterol measures for women. Whether lipoprotein subclasses change with menopausal stage is unclear. Given the high prevalence of low cardiorespiratory fitness in midlife women and benefit of cardiovascular disease risk, it is also important to understand the effect of fitness on lipoprotein profiles. This study evaluated the influence of menopausal status and fitness on lipoprotein particles in healthy midlife women. Lipoprotein particles were measured in high- (n = 25) and low- (n = 13) fit perimenopausal and late postmenopausal women, and in high-fit premenopausal (n = 10), perimenopausal (n = 12), and late postmenopausal women (n = 13). There were larger low-density lipoprotein particles (LDL-P; 21.7 ± 0.06 vs. 21.3 ± 0.1 nm, p = 0.002), more large LDL-P (623.1 ± 32.8 vs. 500.2 ± 52.6 nmol/L, p = 0.045), and fewer small LDL-P (145.5 ± 31.4 vs. 311.5 ± 44.7 nmol/L, p = 0.001) in the high-fit group vs. the low-fit group. High-density lipoprotein particles (HDL-P) were larger (10.1 ± 0.1 vs. 9.7 ± 0.1 nm, p = 0.002) in the high-fit group, with more large (14.8 ± 0.7 vs. 11.0 ± 0.9 μmol/L, p = 0.002), medium (12.9 ± 0.8 vs. 8.4 ± 0.9 μmol/L, p = 0.002) HDL-P, and fewer small HDL-P (10.2 ± 1.1 vs. 15.4 ± 1.6 μmol/L, p = 0.009) compared with the low-fit group. High-fit postmenopausal women had more large LDL-P (662.9 ± 47.5 nmol/L) compared with premenopausal women (479.1 ± 52.6 nmol/L, p = 0.035), and more HDL-P (40.2 ± 1.1 µmol/L) compared with premenopausal (34.9 ± 1.5 μmol/L, p = 0.023) and perimenopausal women (35.4 ± 1.3 μmol/L, p = 0.033). High fitness positively influences lipoprotein particles in healthy perimenopausal and late postmenopausal women. In healthy fit women, menopause may not have a large influence on lipoprotein particles. Novelty: In highly fit women, menopause may not have a negative influence on lipoprotein particle subclasses. High fitness is associated with a less atherogenic lipoprotein profile in perimenopausal and late postmenopausal women.
摘要：
脂蛋白颗粒可能提供更好的信息，比标准的胆固醇测量女性心血管风险。脂蛋白亚类是否随绝经阶段而改变尚不清楚。考虑到中年女性心肺功能低下的患病率高，以及心血管疾病风险的益处，了解健身对脂蛋白谱的影响也很重要。这项研究评估了绝经状态和健康状况对健康中年女性脂蛋白颗粒的影响。测量高（n=25）和低（n=13）适合围绝经期和绝经后晚期妇女的脂蛋白颗粒，在高适应绝经前(n=10)，围绝经期（n=12），和绝经晚期妇女（n=13）。低密度脂蛋白颗粒较大（LDL-P;21.7±0.06vs.21.3±0.1nm，p=0.002),更多的LDL-P（623.1±32.8vs.500.2±52.6nmol/L,p=0.045),和较少的小LDL-P（145.5±31.4vs.311.5±44.7nmol/L,p=0.001）在高拟合组中与低拟合组。高密度脂蛋白颗粒（HDL-P）较大（10.1±0.1vs.9.7±0.1nm,p=0.002)在高拟合组中，更大的(14.8±0.7与11.0±0.9μmol/L,p=0.002),中等(12.9±0.8vs.8.4±0.9μmol/L,p=0.002)HDL-P,和更少的小HDL-P(10.2±1.1与15.4±1.6μmol/L,p=0.009）与低拟合组相比。高适应性绝经后妇女的LDL-P（662.9±47.5nmol/L）高于绝经前妇女（479.1±52.6nmol/L，p=0.035),与绝经前相比，HDL-P（40.2±1.1μmol/L）更高（34.9±1.5μmol/L，p=0.023）和围绝经期妇女（35.4±1.3μmol/L，p=0.033)。高适应性对健康围绝经期和绝经后期妇女的脂蛋白颗粒有积极影响。在健康的女性中，更年期对脂蛋白颗粒的影响可能不大。新颖性：在健康女性中，绝经可能不会对脂蛋白颗粒亚类产生负面影响。围绝经期和绝经后期妇女的高适应性与较少的动脉粥样硬化脂蛋白有关。
